PLoS ONE (Jan 2021)

Impact of 1h oral glucose tolerance test on the clinical status of adult cystic fibrosis patients over a 4-year period.

  • Valérie Boudreau,
  • Quitterie Reynaud,
  • Angélique Denis,
  • Johann Colomba,
  • Sandrine Touzet,
  • Katherine Desjardins,
  • Stéphanie Poupon Bourdy,
  • Isabelle Durieu,
  • Rémi Rabasa-Lhoret

DOI
https://doi.org/10.1371/journal.pone.0246897
Journal volume & issue
Vol. 16, no. 3
p. e0246897

Abstract

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ObjectiveTo report the clinical profile associated with G60 and I60 over a 4-year prospective observational period in 2 large cohorts of adult patients with CF.Methods319 patients were included (210 Canadian and 119 French) and classified according to their inclusion G60 (≥ or ResultsHigh G60 was not associated to a lower FEV1 at inclusion and the follow-up decline was not higher in the high G60 group (Coefficient [95% CI]: -3.4 [-7.4;0.6], p = 0.0995.). There was no significant association between BMI and G60. Patients with high I60 tended to have a higher mean BMI (+0.5 kg/m2 [0.0 to 1.1], p = 0.05) but no interaction over time was observed.ConclusionsHigh G60 is not associated with a lower lung function at inclusion nor its decline over a 4-year follow-up. High I60 is slightly associated to a higher weight at inclusion, but not with BMI evolution over time in adult patients.