Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor

Sanja Mikulovic; Carlos Ernesto Restrepo; Samer Siwani; Pavol Bauer; Stefano Pupe; Adriano B. L. Tort; Klas Kullander; Richardson N. Leão

doi:10.1038/s41467-018-05907-w

Nature Communications (Sep 2018)

Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor

Sanja Mikulovic,
Carlos Ernesto Restrepo,
Samer Siwani,
Pavol Bauer,
Stefano Pupe,
Adriano B. L. Tort,
Klas Kullander,
Richardson N. Leão

Affiliations

Sanja Mikulovic: Developmental Genetics, Department of Neuroscience, Uppsala University
Carlos Ernesto Restrepo: Developmental Genetics, Department of Neuroscience, Uppsala University
Samer Siwani: Developmental Genetics, Department of Neuroscience, Uppsala University
Pavol Bauer: Division of Scientific Computing, Department of Information Technology, Uppsala University
Stefano Pupe: Developmental Genetics, Department of Neuroscience, Uppsala University
Adriano B. L. Tort: Brain Institute, Federal University of Rio Grande do Norte
Klas Kullander: Developmental Genetics, Department of Neuroscience, Uppsala University
Richardson N. Leão: Developmental Genetics, Department of Neuroscience, Uppsala University

DOI: https://doi.org/10.1038/s41467-018-05907-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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There are two subtypes of hippocampal theta oscillations that differ in frequency range, pharmacology, and behavioural correlates. Here, the authors report that activity of OLM interneurons in the ventral hippocampus mediates type 2 theta, associated with increased risk-taking in the presence of predator threat.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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