Nature Communications (Apr 2021)
Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor
- Zizheng Zou,
- Xiyuan Hu,
- Tiao Luo,
- Zhengnan Ming,
- Xiaodan Chen,
- Li Xia,
- Wensong Luo,
- Jijia Li,
- Na Xu,
- Ling Chen,
- Dongsheng Cao,
- Min Wen,
- Fanrong Kong,
- Kunjian Peng,
- Yuanzhu Xie,
- Xuan Li,
- Dayou Ma,
- Chuanyu Yang,
- Ceshi Chen,
- Wenjun Yi,
- Ousheng Liu,
- Suyou Liu,
- Junli Luo,
- Zhiyong Luo
Affiliations
- Zizheng Zou
- Department of Biochemistry and Molecular Biology, Hunan Province Key Laboratory of Basic and Applied Hematology, Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Xiangya School of Medicine, Central South University
- Xiyuan Hu
- Department of Biochemistry and Molecular Biology, Hunan Province Key Laboratory of Basic and Applied Hematology, Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Xiangya School of Medicine, Central South University
- Tiao Luo
- Hunan Key Laboratory of Oral Health Research & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University
- Zhengnan Ming
- Department of Biochemistry and Molecular Biology, Hunan Province Key Laboratory of Basic and Applied Hematology, Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Xiangya School of Medicine, Central South University
- Xiaodan Chen
- Department of Biochemistry and Molecular Biology, Hunan Province Key Laboratory of Basic and Applied Hematology, Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Xiangya School of Medicine, Central South University
- Li Xia
- Core Facility of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Wensong Luo
- Department of Biochemistry and Molecular Biology, Hunan Province Key Laboratory of Basic and Applied Hematology, Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Xiangya School of Medicine, Central South University
- Jijia Li
- The Hunan Provincial Key Laboratory of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University
- Na Xu
- Xiangya School of Pharmaceutical Sciences, Central South University
- Ling Chen
- Xiangya School of Pharmaceutical Sciences, Central South University
- Dongsheng Cao
- Xiangya School of Pharmaceutical Sciences, Central South University
- Min Wen
- Department of Biochemistry and Molecular Biology, Hunan Province Key Laboratory of Basic and Applied Hematology, Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Xiangya School of Medicine, Central South University
- Fanrong Kong
- Department of Biochemistry and Molecular Biology, Hunan Province Key Laboratory of Basic and Applied Hematology, Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Xiangya School of Medicine, Central South University
- Kunjian Peng
- Department of Biochemistry and Molecular Biology, Hunan Province Key Laboratory of Basic and Applied Hematology, Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Xiangya School of Medicine, Central South University
- Yuanzhu Xie
- Department of Biochemistry and Molecular Biology, Hunan Province Key Laboratory of Basic and Applied Hematology, Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Xiangya School of Medicine, Central South University
- Xuan Li
- Department of Biochemistry and Molecular Biology, Hunan Province Key Laboratory of Basic and Applied Hematology, Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Xiangya School of Medicine, Central South University
- Dayou Ma
- Xiangya School of Pharmaceutical Sciences, Central South University
- Chuanyu Yang
- Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences
- Ceshi Chen
- Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences
- Wenjun Yi
- Department of General Surgery, The Second Xiangya Hospital, Central South University
- Ousheng Liu
- Hunan Key Laboratory of Oral Health Research & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University
- Suyou Liu
- Xiangya School of Pharmaceutical Sciences, Central South University
- Junli Luo
- The Hunan Provincial Key Laboratory of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University
- Zhiyong Luo
- Department of Biochemistry and Molecular Biology, Hunan Province Key Laboratory of Basic and Applied Hematology, Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Xiangya School of Medicine, Central South University
- DOI
- https://doi.org/10.1038/s41467-021-22235-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.
