Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance

Chao-Yue Cui; Qian He; Qiu-Lin Jia; Cang Li; Chong Chen; Xiao-Ting Wu; Xiao-Jing Zhang; Zhuo-Yu Lin; Zi-Jian Zheng; Xiao-Ping Liao; Barry N. Kreiswirth; Ya-Hong Liu; Liang Chen; Jian Sun

doi:10.1128/mSystems.00050-21

mSystems (Jun 2021)

Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance

Chao-Yue Cui,
Qian He,
Qiu-Lin Jia,
Cang Li,
Chong Chen,
Xiao-Ting Wu,
Xiao-Jing Zhang,
Zhuo-Yu Lin,
Zi-Jian Zheng,
Xiao-Ping Liao,
Barry N. Kreiswirth,
Ya-Hong Liu,
Liang Chen,
Jian Sun

Affiliations

Chao-Yue Cui: Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Qian He: Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Qiu-Lin Jia: Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Cang Li: Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Chong Chen: ORCiD; Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Xiao-Ting Wu: Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Xiao-Jing Zhang: Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Zhuo-Yu Lin: Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Zi-Jian Zheng: Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Xiao-Ping Liao: ORCiD; Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Barry N. Kreiswirth: Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA
Ya-Hong Liu: Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
Liang Chen: ORCiD; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA
Jian Sun: ORCiD; Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

DOI: https://doi.org/10.1128/mSystems.00050-21
Journal volume & issue: Vol. 6, no. 3

Abstract

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The newly emerged tigecycline-inactivating enzymes Tet(X3) and Tet(X4), which are associated with high-level tigecycline resistance, demonstrated significantly higher activities in comparison to that of the prototypical Tet(X) enzyme, threatening the clinical efficacy of tigecycline as a last-resort antibiotic to treat multidrug-resistant (MDR) Gram-negative bacterial infections. However, the molecular mechanisms leading to high-level tigecycline resistance remain elusive.

Published in mSystems

ISSN: 2379-5077 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msystems

About the journal