Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation

Alexis Osseni; Aymeric Ravel-Chapuis; Edwige Belotti; Isabella Scionti; Yann-Gaël Gangloff; Vincent Moncollin; Laetitia Mazelin; Remi Mounier; Pascal Leblanc; Bernard J. Jasmin; Laurent Schaeffer

doi:10.1038/s41467-022-34831-3

Nature Communications (Nov 2022)

Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation

Alexis Osseni,
Aymeric Ravel-Chapuis,
Edwige Belotti,
Isabella Scionti,
Yann-Gaël Gangloff,
Vincent Moncollin,
Laetitia Mazelin,
Remi Mounier,
Pascal Leblanc,
Bernard J. Jasmin,
Laurent Schaeffer

Affiliations

Alexis Osseni: Pathophysiology and Genetics of Neuron and Muscle (INMG-PGNM), CNRS UMR 5261, INSERM U 1315, Université de Lyon
Aymeric Ravel-Chapuis: Department of Cellular and Molecular Medicine, Faculty of Medicine, 451 Smyth Road, University of Ottawa
Edwige Belotti: Pathophysiology and Genetics of Neuron and Muscle (INMG-PGNM), CNRS UMR 5261, INSERM U 1315, Université de Lyon
Isabella Scionti: Pathophysiology and Genetics of Neuron and Muscle (INMG-PGNM), CNRS UMR 5261, INSERM U 1315, Université de Lyon
Yann-Gaël Gangloff: Pathophysiology and Genetics of Neuron and Muscle (INMG-PGNM), CNRS UMR 5261, INSERM U 1315, Université de Lyon
Vincent Moncollin: Pathophysiology and Genetics of Neuron and Muscle (INMG-PGNM), CNRS UMR 5261, INSERM U 1315, Université de Lyon
Laetitia Mazelin: Pathophysiology and Genetics of Neuron and Muscle (INMG-PGNM), CNRS UMR 5261, INSERM U 1315, Université de Lyon
Remi Mounier: Pathophysiology and Genetics of Neuron and Muscle (INMG-PGNM), CNRS UMR 5261, INSERM U 1315, Université de Lyon
Pascal Leblanc: Pathophysiology and Genetics of Neuron and Muscle (INMG-PGNM), CNRS UMR 5261, INSERM U 1315, Université de Lyon
Bernard J. Jasmin: Department of Cellular and Molecular Medicine, Faculty of Medicine, 451 Smyth Road, University of Ottawa
Laurent Schaeffer: Pathophysiology and Genetics of Neuron and Muscle (INMG-PGNM), CNRS UMR 5261, INSERM U 1315, Université de Lyon

DOI: https://doi.org/10.1038/s41467-022-34831-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Here, authors show that Smad3 acetylation via HDAC6 inhibition reverses Duchenne muscular dystrophy-like symptoms in the mdx mouse model, suggesting a potential therapeutic target for the disorder.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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