Frontiers in Bioengineering and Biotechnology (Oct 2022)
Antibacterial and anti-inflammatory ZIF-8@Rutin nanocomposite as an efficient agent for accelerating infected wound healing
- Xiaomin Xia,
- Xiaomin Xia,
- Xiaomin Xia,
- Xiaomin Xia,
- Xujun Song,
- Xujun Song,
- Xujun Song,
- Xujun Song,
- Ying Li,
- Ying Li,
- Ying Li,
- Ying Li,
- Wenxue Hou,
- Wenxue Hou,
- Wenxue Hou,
- Wenxue Hou,
- Hanlin Lv,
- Hanlin Lv,
- Hanlin Lv,
- Hanlin Lv,
- Feng Li,
- Feng Li,
- Feng Li,
- Feng Li,
- Yanan Li,
- Yanan Li,
- Yanan Li,
- Yanan Li,
- Jie Liu,
- Jie Liu,
- Jie Liu,
- Jie Liu,
- Xue Li,
- Xue Li,
- Xue Li,
- Xue Li
Affiliations
- Xiaomin Xia
- Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China
- Xiaomin Xia
- School of Stomatology, Qingdao University, Qingdao, Shandong, China
- Xiaomin Xia
- Dental Digital Medicine and 3D Printing Engineering Laboratory of Qingdao, Qingdao, Shandong, China
- Xiaomin Xia
- Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, Shandong, China
- Xujun Song
- Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China
- Xujun Song
- School of Stomatology, Qingdao University, Qingdao, Shandong, China
- Xujun Song
- Dental Digital Medicine and 3D Printing Engineering Laboratory of Qingdao, Qingdao, Shandong, China
- Xujun Song
- Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, Shandong, China
- Ying Li
- Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China
- Ying Li
- School of Stomatology, Qingdao University, Qingdao, Shandong, China
- Ying Li
- Dental Digital Medicine and 3D Printing Engineering Laboratory of Qingdao, Qingdao, Shandong, China
- Ying Li
- Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, Shandong, China
- Wenxue Hou
- Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China
- Wenxue Hou
- School of Stomatology, Qingdao University, Qingdao, Shandong, China
- Wenxue Hou
- Dental Digital Medicine and 3D Printing Engineering Laboratory of Qingdao, Qingdao, Shandong, China
- Wenxue Hou
- Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, Shandong, China
- Hanlin Lv
- Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China
- Hanlin Lv
- School of Stomatology, Qingdao University, Qingdao, Shandong, China
- Hanlin Lv
- Dental Digital Medicine and 3D Printing Engineering Laboratory of Qingdao, Qingdao, Shandong, China
- Hanlin Lv
- Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, Shandong, China
- Feng Li
- Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China
- Feng Li
- School of Stomatology, Qingdao University, Qingdao, Shandong, China
- Feng Li
- Dental Digital Medicine and 3D Printing Engineering Laboratory of Qingdao, Qingdao, Shandong, China
- Feng Li
- Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, Shandong, China
- Yanan Li
- Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China
- Yanan Li
- School of Stomatology, Qingdao University, Qingdao, Shandong, China
- Yanan Li
- Dental Digital Medicine and 3D Printing Engineering Laboratory of Qingdao, Qingdao, Shandong, China
- Yanan Li
- Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, Shandong, China
- Jie Liu
- Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China
- Jie Liu
- School of Stomatology, Qingdao University, Qingdao, Shandong, China
- Jie Liu
- Dental Digital Medicine and 3D Printing Engineering Laboratory of Qingdao, Qingdao, Shandong, China
- Jie Liu
- Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, Shandong, China
- Xue Li
- Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China
- Xue Li
- School of Stomatology, Qingdao University, Qingdao, Shandong, China
- Xue Li
- Dental Digital Medicine and 3D Printing Engineering Laboratory of Qingdao, Qingdao, Shandong, China
- Xue Li
- Dental Biomaterials Technology Innovation Center of Qingdao, Qingdao, Shandong, China
- DOI
- https://doi.org/10.3389/fbioe.2022.1026743
- Journal volume & issue
-
Vol. 10
Abstract
Essentially, wound healing is a complicated physiological process in which there exists an interaction between the organism’s immune regulation and antimicrobial therapy. However, multiple drug-resistant bacteria implicated in chronic non-healing wound are not merely impeding the cure process, but more than a burden on economic and social development. Due to the inefficiency of conventional antibiotics, nanomedicine in the biomedical field is emerging as a prospective anti-infective therapy method. Herein, a novel nano-drug with antibacterial and anti-inflammatory characteristics was synthesized by loading Rutin into zeolitic imidazolate framework-8 (ZIF-8), abided by the principle of electrostatic adsorption. The synthetic ZIF-8 loaded Rutin (ZIF-8@Rutin) was affirmed by testing the changes in the diameter and chemical functional group. Interestingly, the ladened Rutin afforded nanocomposite with anti-inflammatory activity by its antioxidant capacity for the polarization of macrophages. Further, the prepared ZIF-8@Rutin exhibited highly effective antibacterial activity against Escherichia coli and Staphylococcus aureus in vitro. More importantly, it could shorten the infected wound healing process and alleviate the inflammation around the wound in vivo. Also, ZIF-8@Rutin had acceptable cytocompatibility. Thus, ZIF-8@Rutin may become a multifunctional nanomedicine with anti-inflammatory and bactericidal properties to promote infected wound healing.
Keywords
