The study of pharmacodynamics of a medicine based on humanized monoclonal antibodies against IL-17 in rabbit model of antigen-induced arthritis

Abstract

The present article contains scientific data on the assessment of specific activity of therapeutic humanized monoclonal antibodies against IL-17 in rabbit model of antigen-induced arthritis. Pharmacokinetics and immunogenicity of anti-IL-17A preparation have been studied. The severity of rheumatoid arthritis progression has been assessed by the levels of joint damage, the levels of inflammatory markers and according to Menkin histological grade.

Keywords

• ревматоидный артрит
• моноклональные антитела
• интерлейкина-17 (il-17a)
• crp
• tnf-α
• rheumatoid arthritis
• monoclonal antibodies
• interleukin-17 (il-17a)
• crp
• tnf-α