B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids

Helia N. Sanchez; Justin B. Moroney; Huoqun Gan; Tian Shen; John L. Im; Tianbao Li; Julia R. Taylor; Hong Zan; Paolo Casali

doi:10.1038/s41467-019-13603-6

Nature Communications (Jan 2020)

B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids

Helia N. Sanchez,
Justin B. Moroney,
Huoqun Gan,
Tian Shen,
John L. Im,
Tianbao Li,
Julia R. Taylor,
Hong Zan,
Paolo Casali

Affiliations

Helia N. Sanchez: Department of Microbiology, Immunology & Molecular Genetics, University of Texas Long School of Medicine, UT Health Science Center
Justin B. Moroney: Department of Microbiology, Immunology & Molecular Genetics, University of Texas Long School of Medicine, UT Health Science Center
Huoqun Gan: Department of Microbiology, Immunology & Molecular Genetics, University of Texas Long School of Medicine, UT Health Science Center
Tian Shen: Department of Microbiology, Immunology & Molecular Genetics, University of Texas Long School of Medicine, UT Health Science Center
John L. Im: Department of Microbiology, Immunology & Molecular Genetics, University of Texas Long School of Medicine, UT Health Science Center
Tianbao Li: Department of Molecular Medicine, University of Texas Long School of Medicine, UT Health Science Center
Julia R. Taylor: Department of Microbiology, Immunology & Molecular Genetics, University of Texas Long School of Medicine, UT Health Science Center
Hong Zan: Department of Microbiology, Immunology & Molecular Genetics, University of Texas Long School of Medicine, UT Health Science Center
Paolo Casali: Department of Microbiology, Immunology & Molecular Genetics, University of Texas Long School of Medicine, UT Health Science Center

DOI: https://doi.org/10.1038/s41467-019-13603-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 19

Abstract

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Dietary fiber-derived short-chain fatty acids (SCFA) act as histone deacetylase (HDAC) inhibitors on Tregs and innate immune cells, promoting immune tolerance by altering gene expression. Here the authors show that SCFA HDAC inhibitor activity impacts B cell differentiation, antibody responses and antibody-driven autoimmunity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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