Journal of Clinical Medicine (Sep 2023)
Rest and Stress Left Atrial Dysfunction in Patients with Atrial Fibrillation
- Angela Zagatina,
- Maria Rivadeneira Ruiz,
- Quirino Ciampi,
- Karina Wierzbowska-Drabik,
- Jaroslaw Kasprzak,
- Elena Kalinina,
- Irina Begidova,
- Jesus Peteiro,
- Rosina Arbucci,
- Sofia Marconi,
- Jorge Lowenstein,
- Alla Boshchenko,
- Fiore Manganelli,
- Jelena Čelutkienė,
- Doralisa Morrone,
- Elisa Merli,
- Federica Re,
- Clarissa Borguezan-Daros,
- Maciej Haberka,
- Ariel K. Saad,
- Ana Djordjevic-Dikic,
- Nithima Chaowalit Ratanasit,
- Fausto Rigo,
- Paolo Colonna,
- José Luis de Castro e Silva Pretto,
- Fabio Mori,
- Maria Grazia D’Alfonso,
- Miodrag Ostojic,
- Bojan Stanetic,
- Tamara Kovacevic Preradovic,
- Fabio Costantino,
- Andrea Barbieri,
- Rodolfo Citro,
- Annalisa Pitino,
- Mauro Pepi,
- Scipione Carerj,
- Patricia A. Pellikka,
- Eugenio Picano
Affiliations
- Angela Zagatina
- Cardiology Department, Research Scientific Cardiocenter “Medika”, 197110 St. Petersburg, Russia
- Maria Rivadeneira Ruiz
- Cardiology Department, University Hospital of Virgen Macarena, 41009 Seville, Spain
- Quirino Ciampi
- Fatebenefratelli Hospital of Benevento, 82100 Benevento, Italy
- Karina Wierzbowska-Drabik
- Department of Internal Disease and Clinical Pharmacology, Medical University, 93-510 Lodz, Poland
- Jaroslaw Kasprzak
- Cardiology Department, Bieganski Hospital, Medical University, 93-510 Lodz, Poland
- Elena Kalinina
- Cardiology Department, Research Scientific Cardiocenter “Medika”, 197110 St. Petersburg, Russia
- Irina Begidova
- Cardiology Department, Research Scientific Cardiocenter “Medika”, 197110 St. Petersburg, Russia
- Jesus Peteiro
- CHUAC—Complexo Hospitalario Universitario A Coruna, University of A Coruna, 15071 La Coruna, Spain
- Rosina Arbucci
- Cardiodiagnosticos, Investigaciones Medicas Center, Buenos Aires C1082, Argentina
- Sofia Marconi
- Cardiodiagnosticos, Investigaciones Medicas Center, Buenos Aires C1082, Argentina
- Jorge Lowenstein
- Cardiodiagnosticos, Investigaciones Medicas Center, Buenos Aires C1082, Argentina
- Alla Boshchenko
- Cardiology Research Institute, Tomsk National Research Medical Centre of the Russian Academy of Sciences, 634028 Tomsk, Russia
- Fiore Manganelli
- Cardiology Department, SG Moscati Hospital, 83100 Avellino, Italy
- Jelena Čelutkienė
- Centre of Cardiology and Angiology, Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Centre of Innovative Medicine, LT-10257 Vilnius, Lithuania
- Doralisa Morrone
- Cardiothoracic Department, University of Pisa, 56126 Pisa, Italy
- Elisa Merli
- Department of Cardiology, Ospedale per gli Infermi, Faenza, 48100 Ravenna, Italy
- Federica Re
- Department of Cardiology, Ospedale San Camillo, 00149 Roma, Italy
- Clarissa Borguezan-Daros
- Cardiology Division, Hospital San José, Criciuma 88801-250, Brazil
- Maciej Haberka
- Department of Cardiology, SHS, Medical University of Silesia, 40-635 Katowice, Poland
- Ariel K. Saad
- División de Cardiología, Hospital de Clínicas José de San Martín, Buenos Aires C1120, Argentina
- Ana Djordjevic-Dikic
- Cardiology Clinic, University Center Serbia, Medical School, University of Belgrade, 11000 Belgrade, Serbia
- Nithima Chaowalit Ratanasit
- Division of Cardiology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
- Fausto Rigo
- Department of Cardiology, Dolo Hospital, 30031 Venice, Italy
- Paolo Colonna
- Cardiology Division, Bari University Hospital, 70100 Bari, Italy
- José Luis de Castro e Silva Pretto
- Hospital Sao Vicente de Paulo e Hospital de Cidade, Passo Fundo 99010-080, Brazil
- Fabio Mori
- SOD Diagnostica Cardiovascolare, DAI Cardio-Toraco-Vascolare, Azienda Ospedaliera-Universitaria Careggi, 50139 Firenze, Italy
- Maria Grazia D’Alfonso
- SOD Diagnostica Cardiovascolare, DAI Cardio-Toraco-Vascolare, Azienda Ospedaliera-Universitaria Careggi, 50139 Firenze, Italy
- Miodrag Ostojic
- Department of Noninvasive Cardiology, University Clinical Center, School of Medicine, 78000 Banja-Luka, Bosnia and Herzegovina
- Bojan Stanetic
- Department of Noninvasive Cardiology, University Clinical Center, School of Medicine, 78000 Banja-Luka, Bosnia and Herzegovina
- Tamara Kovacevic Preradovic
- Department of Noninvasive Cardiology, University Clinical Center, School of Medicine, 78000 Banja-Luka, Bosnia and Herzegovina
- Fabio Costantino
- Cardiology Division, San Carlo Hospital, 85100 Potenza, Italy
- Andrea Barbieri
- Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, 41124 Modena, Italy
- Rodolfo Citro
- Cardiology Division, Ospedale Ruggi di Aragona, 84100 Salerno, Italy
- Annalisa Pitino
- CNR, Institute of Clinical Physiology, 56124 Pisa, Italy
- Mauro Pepi
- Centro Cardiologico Monzino, IRCCS, 20138 Milano, Italy
- Scipione Carerj
- Cardiology Division, University Hospital Polyclinic G.Martino, University of Messina, 98166 Messina, Italy
- Patricia A. Pellikka
- Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55901, USA
- Eugenio Picano
- CNR, Institute of Clinical Physiology, 56124 Pisa, Italy
- DOI
- https://doi.org/10.3390/jcm12185893
- Journal volume & issue
-
Vol. 12,
no. 18
p. 5893
Abstract
Background: Left atrial (LA) myopathy with paroxysmal and permanent atrial fibrillation (AF) is frequent in chronic coronary syndromes (CCS) but sometimes occult at rest and elicited by stress. Aim: This study sought to assess LA volume and function at rest and during stress across the spectrum of AF. Methods: In a prospective, multicenter, observational study design, we enrolled 3042 patients [age = 64 ± 12; 63.8% male] with known or suspected CCS: 2749 were in sinus rhythm (SR, Group 1); 191 in SR with a history of paroxysmal AF (Group 2); and 102 were in permanent AF (Group 3). All patients underwent stress echocardiography (SE). We measured left atrial volume index (LAVI) in all patients and LA Strain reservoir phase (LASr) in a subset of 486 patients. Results: LAVI increased from Group 1 to 3, both at rest (Group 1 = 27.6 ± 12.2, Group 2 = 31.6 ± 12.9, Group 3 = 43.3 ± 19.7 mL/m2, p 2, p p p p p = 0.001). Conclusions: In CCS, rest and stress LA dilation and reservoir dysfunction are often present in paroxysmal and, more so, in permanent AF and are associated with more frequent inducible ischemia and pulmonary congestion during stress.
Keywords