Jurnal Farmasi Sains dan Praktis (Dec 2022)

THE RELATIONSHIP BETWEEN SIDE EFFECTS OF TUBERCULOSIS DRUG USE AND SGOT/SGPT VALUE OF INTENSIVE PHASE PATIENTS

  • Farroh Bintang Sabiti,
  • Nur Anna Chalimah Sa’dyah

DOI
https://doi.org/10.31603/pharmacy.v8i3.4721
Journal volume & issue
Vol. 8, no. 3

Abstract

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Tuberculosis is an infectious disease caused by the bacteria Mycobacterium Tuberculosis which has a rod shape and is acid-resistant. The prolonged consumption of anti-tuberculosis drugs can cause serious side effects. Side effects from the consumption of anti-tuberculosis drugs, namely the risk of hepatotoxicity, which is marked by an increase in the SGOT / SGPT value. This study aimed to determine the relationship between the duration of use, dosage and side effects of anti-tuberculosis drugs in tuberculosis patients, which had an effect on the SGOT / SGPT value at RSI Sultan Agung Semarang. This research is an analytical observational study with a cross-sectional design. The sample was 96 patients, and data collection was carried out in January-November 2020 at RSI Semarang. The instrument used in this study was patient medic record data. This study uses the Chi-Square test. The Chi-Square test results in 0.000 (p <0.05) so that it could be stated that there was a relationship between the use and side effects on the SGOT / SGPT value.

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