LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling

Jie Luo; Keliang Wang; Shuyuan Yeh; Yin Sun; Liang Liang; Yao Xiao; Wanhai Xu; Yuanjie Niu; Liang Cheng; Sankar N. Maity; Runze Jiang; Chawnshang Chang

doi:10.1038/s41467-019-09784-9

Nature Communications (Jun 2019)

LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling

Jie Luo,
Keliang Wang,
Shuyuan Yeh,
Yin Sun,
Liang Liang,
Yao Xiao,
Wanhai Xu,
Yuanjie Niu,
Liang Cheng,
Sankar N. Maity,
Runze Jiang,
Chawnshang Chang

Affiliations

Jie Luo: George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, Biology and The Wilmot Cancer Institute, University of Rochester
Keliang Wang: George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, Biology and The Wilmot Cancer Institute, University of Rochester
Shuyuan Yeh: George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, Biology and The Wilmot Cancer Institute, University of Rochester
Yin Sun: George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, Biology and The Wilmot Cancer Institute, University of Rochester
Liang Liang: Department of Urology, Shanxi Province People’s Hospital
Yao Xiao: George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, Biology and The Wilmot Cancer Institute, University of Rochester
Wanhai Xu: Department of Urology, The 4th Affiliated Hospital of Harbin Medical University
Yuanjie Niu: Tianjin Institute of Urology, Tianjin Medical University
Liang Cheng: Department of Pathology & Laboratory Medicine, Indiana University
Sankar N. Maity: Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center
Runze Jiang: Jiangmen Maternity and Child Health Care Hospital
Chawnshang Chang: George Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology, Biology and The Wilmot Cancer Institute, University of Rochester

DOI: https://doi.org/10.1038/s41467-019-09784-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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The induction of neuroendocrine differentiation occurs in enzalutamide treated castration resistant prostate cancer. Here, the authors show that lncRNA-21 mediates enzalutamide induced neuroendocrine differentiation through EZH2/STAT axis and EZH2 inhibition suppresses this differentiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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