Nature Communications (Dec 2016)
Heritability of the shape of subcortical brain structures in the general population
- Gennady V. Roshchupkin,
- Boris A. Gutman,
- Meike W. Vernooij,
- Neda Jahanshad,
- Nicholas G. Martin,
- Albert Hofman,
- Katie L. McMahon,
- Sven J. van der Lee,
- Cornelia M. van Duijn,
- Greig I. de Zubicaray,
- André G. Uitterlinden,
- Margaret J. Wright,
- Wiro J. Niessen,
- Paul M. Thompson,
- M. Arfan Ikram,
- Hieab H. H. Adams
Affiliations
- Gennady V. Roshchupkin
- Department of Radiology and Nuclear Medicine, Erasmus MC
- Boris A. Gutman
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey
- Meike W. Vernooij
- Department of Radiology and Nuclear Medicine, Erasmus MC
- Neda Jahanshad
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey
- Nicholas G. Martin
- QIMR Berghofer Medical Research Institute
- Albert Hofman
- Department of Epidemiology, Erasmus MC
- Katie L. McMahon
- Centre for Advanced Imaging, The University of Queensland
- Sven J. van der Lee
- Department of Epidemiology, Erasmus MC
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus MC
- Greig I. de Zubicaray
- Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology
- André G. Uitterlinden
- Department of Internal Medicine, Erasmus MC
- Margaret J. Wright
- Centre for Advanced Imaging, The University of Queensland
- Wiro J. Niessen
- Department of Radiology and Nuclear Medicine, Erasmus MC
- Paul M. Thompson
- Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey
- M. Arfan Ikram
- Department of Radiology and Nuclear Medicine, Erasmus MC
- Hieab H. H. Adams
- Department of Radiology and Nuclear Medicine, Erasmus MC
- DOI
- https://doi.org/10.1038/ncomms13738
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 8
Abstract
The volume of subcortical brain structures is known to be heritable. Here, Roshchupkin and colleagues studied seven different subcortical brain structures in the general population and show that the genetic contributions go beyond these volumetric measurements, and also extend to their shapes.
