The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA

Luxia Yao; Yihan Wang; Shenlu Qin; Shihao Zhu; Lianfeng Wu

doi:10.1038/s42003-023-04475-0

Communications Biology (Jan 2023)

The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA

Luxia Yao,
Yihan Wang,
Shenlu Qin,
Shihao Zhu,
Lianfeng Wu

Affiliations

Luxia Yao: Fudan University
Yihan Wang: Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University
Shenlu Qin: Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University
Shihao Zhu: Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University
Lianfeng Wu: Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University

DOI: https://doi.org/10.1038/s42003-023-04475-0
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 10

Abstract

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The antidiabetic drug, metformin, helps E. coli gather vitamin B12 from the environment by increasing the expressions of transporter genes in a RcdA-dependent manner.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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