Frontiers in Cell and Developmental Biology (Sep 2023)
The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes
- Houwen Pan,
- Houwen Pan,
- Houwen Pan,
- Houwen Pan,
- Houwen Pan,
- Houwen Pan,
- Yiling Yang,
- Yiling Yang,
- Yiling Yang,
- Yiling Yang,
- Yiling Yang,
- Yiling Yang,
- Hongyuan Xu,
- Hongyuan Xu,
- Hongyuan Xu,
- Hongyuan Xu,
- Hongyuan Xu,
- Hongyuan Xu,
- Anting Jin,
- Anting Jin,
- Anting Jin,
- Anting Jin,
- Anting Jin,
- Anting Jin,
- Xiangru Huang,
- Xiangru Huang,
- Xiangru Huang,
- Xiangru Huang,
- Xiangru Huang,
- Xiangru Huang,
- Xin Gao,
- Xin Gao,
- Xin Gao,
- Xin Gao,
- Xin Gao,
- Xin Gao,
- Siyuan Sun,
- Siyuan Sun,
- Siyuan Sun,
- Siyuan Sun,
- Siyuan Sun,
- Siyuan Sun,
- Yuanqi Liu,
- Yuanqi Liu,
- Yuanqi Liu,
- Yuanqi Liu,
- Yuanqi Liu,
- Yuanqi Liu,
- Jingyi Liu,
- Jingyi Liu,
- Jingyi Liu,
- Jingyi Liu,
- Jingyi Liu,
- Jingyi Liu,
- Tingwei Lu,
- Tingwei Lu,
- Tingwei Lu,
- Tingwei Lu,
- Tingwei Lu,
- Tingwei Lu,
- Xinyu Wang,
- Xinyu Wang,
- Xinyu Wang,
- Xinyu Wang,
- Xinyu Wang,
- Xinyu Wang,
- Yanfei Zhu,
- Yanfei Zhu,
- Yanfei Zhu,
- Yanfei Zhu,
- Yanfei Zhu,
- Yanfei Zhu,
- Lingyong Jiang,
- Lingyong Jiang,
- Lingyong Jiang,
- Lingyong Jiang,
- Lingyong Jiang,
- Lingyong Jiang
Affiliations
- Houwen Pan
- Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Houwen Pan
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Houwen Pan
- National Center for Stomatology, Shanghai, China
- Houwen Pan
- National Clinical Research Center for Oral Disease, Shanghai, China
- Houwen Pan
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Houwen Pan
- Shanghai Research Institute of Stomatology, Shanghai, China
- Yiling Yang
- Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yiling Yang
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Yiling Yang
- National Center for Stomatology, Shanghai, China
- Yiling Yang
- National Clinical Research Center for Oral Disease, Shanghai, China
- Yiling Yang
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Yiling Yang
- Shanghai Research Institute of Stomatology, Shanghai, China
- Hongyuan Xu
- Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Hongyuan Xu
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Hongyuan Xu
- National Center for Stomatology, Shanghai, China
- Hongyuan Xu
- National Clinical Research Center for Oral Disease, Shanghai, China
- Hongyuan Xu
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Hongyuan Xu
- Shanghai Research Institute of Stomatology, Shanghai, China
- Anting Jin
- Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Anting Jin
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Anting Jin
- National Center for Stomatology, Shanghai, China
- Anting Jin
- National Clinical Research Center for Oral Disease, Shanghai, China
- Anting Jin
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Anting Jin
- Shanghai Research Institute of Stomatology, Shanghai, China
- Xiangru Huang
- Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Xiangru Huang
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Xiangru Huang
- National Center for Stomatology, Shanghai, China
- Xiangru Huang
- National Clinical Research Center for Oral Disease, Shanghai, China
- Xiangru Huang
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Xiangru Huang
- Shanghai Research Institute of Stomatology, Shanghai, China
- Xin Gao
- Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Xin Gao
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Xin Gao
- National Center for Stomatology, Shanghai, China
- Xin Gao
- National Clinical Research Center for Oral Disease, Shanghai, China
- Xin Gao
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Xin Gao
- Shanghai Research Institute of Stomatology, Shanghai, China
- Siyuan Sun
- Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Siyuan Sun
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Siyuan Sun
- National Center for Stomatology, Shanghai, China
- Siyuan Sun
- National Clinical Research Center for Oral Disease, Shanghai, China
- Siyuan Sun
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Siyuan Sun
- Shanghai Research Institute of Stomatology, Shanghai, China
- Yuanqi Liu
- Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yuanqi Liu
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Yuanqi Liu
- National Center for Stomatology, Shanghai, China
- Yuanqi Liu
- National Clinical Research Center for Oral Disease, Shanghai, China
- Yuanqi Liu
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Yuanqi Liu
- Shanghai Research Institute of Stomatology, Shanghai, China
- Jingyi Liu
- Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Jingyi Liu
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Jingyi Liu
- National Center for Stomatology, Shanghai, China
- Jingyi Liu
- National Clinical Research Center for Oral Disease, Shanghai, China
- Jingyi Liu
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Jingyi Liu
- Shanghai Research Institute of Stomatology, Shanghai, China
- Tingwei Lu
- Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Tingwei Lu
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Tingwei Lu
- National Center for Stomatology, Shanghai, China
- Tingwei Lu
- National Clinical Research Center for Oral Disease, Shanghai, China
- Tingwei Lu
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Tingwei Lu
- Shanghai Research Institute of Stomatology, Shanghai, China
- Xinyu Wang
- Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Xinyu Wang
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Xinyu Wang
- National Center for Stomatology, Shanghai, China
- Xinyu Wang
- National Clinical Research Center for Oral Disease, Shanghai, China
- Xinyu Wang
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Xinyu Wang
- Shanghai Research Institute of Stomatology, Shanghai, China
- Yanfei Zhu
- Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yanfei Zhu
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Yanfei Zhu
- National Center for Stomatology, Shanghai, China
- Yanfei Zhu
- National Clinical Research Center for Oral Disease, Shanghai, China
- Yanfei Zhu
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Yanfei Zhu
- Shanghai Research Institute of Stomatology, Shanghai, China
- Lingyong Jiang
- Center of Craniofacial Orthodontics, Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Lingyong Jiang
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Lingyong Jiang
- National Center for Stomatology, Shanghai, China
- Lingyong Jiang
- National Clinical Research Center for Oral Disease, Shanghai, China
- Lingyong Jiang
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Lingyong Jiang
- Shanghai Research Institute of Stomatology, Shanghai, China
- DOI
- https://doi.org/10.3389/fcell.2023.1174579
- Journal volume & issue
-
Vol. 11
Abstract
Dental mesenchymal stem cells (DMSCs) are multipotent progenitor cells that can differentiate into multiple lineages including odontoblasts, osteoblasts, chondrocytes, neural cells, myocytes, cardiomyocytes, adipocytes, endothelial cells, melanocytes, and hepatocytes. Odontoblastic differentiation of DMSCs is pivotal in dentinogenesis, a delicate and dynamic process regulated at the molecular level by signaling pathways, transcription factors, and posttranscriptional and epigenetic regulation. Mutations or dysregulation of related genes may contribute to genetic diseases with dentin defects caused by impaired odontoblastic differentiation, including tricho-dento-osseous (TDO) syndrome, X-linked hypophosphatemic rickets (XLH), Raine syndrome (RS), hypophosphatasia (HPP), Schimke immuno-osseous dysplasia (SIOD), and Elsahy-Waters syndrome (EWS). Herein, recent progress in the molecular regulation of the odontoblastic differentiation of DMSCs is summarized. In addition, genetic syndromes associated with disorders of odontoblastic differentiation of DMSCs are discussed. An improved understanding of the molecular regulation and related genetic syndromes may help clinicians better understand the etiology and pathogenesis of dentin lesions in systematic diseases and identify novel treatment targets.
Keywords
- odontoblastic differentiation
- dental mesenchymal stem cells
- molecular regulation
- signaling pathway
- genetic syndrome
