Cancers (May 2022)
No Geographical Inequalities in Survival for Sarcoma Patients in France: A Reference Networks’ Outcome?
- Yohan Fayet,
- Christine Chevreau,
- Gauthier Decanter,
- Cécile Dalban,
- Pierre Meeus,
- Sébastien Carrère,
- Leila Haddag-Miliani,
- François Le Loarer,
- Sylvain Causeret,
- Daniel Orbach,
- Michelle Kind,
- Louis-Romée Le Nail,
- Gwenaël Ferron,
- Hélène Labrosse,
- Loïc Chaigneau,
- François Bertucci,
- Jean-Christophe Ruzic,
- Valérie Le Brun Ly,
- Fadila Farsi,
- Emmanuelle Bompas,
- Sabine Noal,
- Aurore Vozy,
- Agnes Ducoulombier,
- Clément Bonnet,
- Sylvie Chabaud,
- Françoise Ducimetière,
- Camille Tlemsani,
- Mickaël Ropars,
- Olivier Collard,
- Paul Michelin,
- Justine Gantzer,
- Pascale Dubray-Longeras,
- Maria Rios,
- Pauline Soibinet,
- Axel Le Cesne,
- Florence Duffaud,
- Marie Karanian,
- François Gouin,
- Raphaël Tétreau,
- Charles Honoré,
- Jean-Michel Coindre,
- Isabelle Ray-Coquard,
- Sylvie Bonvalot,
- Jean-Yves Blay
Affiliations
- Yohan Fayet
- EMS Team–Human and Social Sciences Department, Centre Léon Bérard, 69008 Lyon, France
- Christine Chevreau
- ICR IUCT-Oncopole, 31000 Toulouse, France
- Gauthier Decanter
- Department of Surgical Oncology, Oscar Lambret Center, 59000 Lille, France
- Cécile Dalban
- Department of Clinical Research and Innovation, Centre Léon Bérard, 69008 Lyon, France
- Pierre Meeus
- Department of Surgery, Centre Léon Bérard, 69008 Lyon, France
- Sébastien Carrère
- Institut de Recherche en Cancérologie Montpellier, INSERM U1194, 34000 Montpellier, France
- Leila Haddag-Miliani
- Service D’imagerie Diagnostique, Institut Gustave Roussy, 94800 Villejuif, France
- François Le Loarer
- Department of Pathology, Institut Bergonié, 33000 Bordeaux, France
- Sylvain Causeret
- Centre Georges François Leclerc, 21000 Dijon, France
- Daniel Orbach
- Centre Oncologie SIREDO (Soins, Innovation et Recherche en Oncologie de l’Enfant, de l’aDOlescents et de L’adulte Jeune), Institut Curie, Université de Recherche Paris Sciences et Lettres, 75005 Paris, France
- Michelle Kind
- Radiologue, Département D’imagerie Médicale, Institut Bergonié, 33000 Bordeaux, France
- Louis-Romée Le Nail
- Department of Orthopaedic Surgery, CHU de Tours, Faculté de Médecine, Université de Tours, 37000 Tours, France
- Gwenaël Ferron
- INSERM CRCT19 ONCO-SARC (Sarcoma Oncogenesis), Institut Claudius Regaud-Institut Universitaire du Cancer, 31000 Toulouse, France
- Hélène Labrosse
- CRLCC Léon Berard, Oncology Regional Network ONCO-AURA, 69008 Lyon, France
- Loïc Chaigneau
- Department of Medical Oncology, CHRU Jean Minjoz, 25000 Besançon, France
- François Bertucci
- Department of Medical Oncology, Institut Paoli-Calmettes, 13009 Marseille, France
- Jean-Christophe Ruzic
- CHU Réunion, 97410 Saint-Pierre, France
- Valérie Le Brun Ly
- Service D’oncologie Médicale, CHU Dupuytren, 87000 Limoges, France
- Fadila Farsi
- CRLCC Léon Berard, Oncology Regional Network ONCO-AURA, 69008 Lyon, France
- Emmanuelle Bompas
- Medical Oncology Department, ICO, 44800 Saint Herblain, France
- Sabine Noal
- UCP Sarcome, Centre François Baclesse, 14000 Caen, France
- Aurore Vozy
- Department of Medical Oncology, Pitié Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Institut Universitaire de Cancérologie (IUC), CLIP(2) Galilée, Sorbonne University, 75013 Paris, France
- Agnes Ducoulombier
- Centre Antoine-Lacassagne, 06000 Nice, France
- Clément Bonnet
- Service d’Oncologie Médicale Hôpital Saint Louis, 75010 Paris, France
- Sylvie Chabaud
- Department of Clinical Research and Innovation, Centre Léon Bérard, 69008 Lyon, France
- Françoise Ducimetière
- Equipe EMS, Centre Léon Bérard, 69008 Lyon, France
- Camille Tlemsani
- Service d’Oncologie Médicale, Hôpital Cochin, Institut du Cancer Paris CARPEM, Université de Paris, APHP Centre, 75014 Paris, France
- Mickaël Ropars
- Orthopaedic and Trauma Department, Pontchaillou University Hospital, University of Rennes 1, 35000 Rennes, France
- Olivier Collard
- Département d’Oncologie Médicale, Hôpital Privé de la Loire, 42100 Saint-Etienne, France
- Paul Michelin
- Service D’imagerie Médicale, CHU Hopitaux de Rouen-Hopital Charles Nicolle, 76000 Rouen, France
- Justine Gantzer
- Department of Medical Oncology, Strasbourg-Europe Cancer Institute (ICANS), 67033 Strasbourg, France
- Pascale Dubray-Longeras
- Oncology Department, Centre Jean Perrin, 63011 Clermont-Ferrand, France
- Maria Rios
- Department of Medical Oncology, Cancer Institute of Lorraine-Alexis Vautrin, 54500 Vandoeuvre Les Nancy, France
- Pauline Soibinet
- Department of Hepato-Gastroenterology and Digestive Oncology, Reims University Hospital, 51000 Reims, France
- Axel Le Cesne
- Medical Oncology, Insitut Gustave Roussy, 94800 Villejuif, France
- Florence Duffaud
- Department of Medical Oncology, CHU La Timone and Aix-Marseille Université (AMU), 13005 Marseille, France
- Marie Karanian
- Department of Pathology, Lyon University Hospital, 69008 Lyon, France
- François Gouin
- Department of Surgery, Centre Léon Bérard, 69008 Lyon, France
- Raphaël Tétreau
- Medical Imaging Center, Institut du Cancer, 34000 Montpellier, France
- Charles Honoré
- Department of Surgical Oncology, Gustave Roussy, Villejuif 94800, France
- Jean-Michel Coindre
- Department of Pathology, Institut Bergonié, 33000 Bordeaux, France
- Isabelle Ray-Coquard
- Department of Medical Oncology, Centre Leon Berard, 69008 Lyon, France
- Sylvie Bonvalot
- Department of Surgical Oncology, Institut Curie, Université Paris Sciences et Lettres, 75005 Paris, France
- Jean-Yves Blay
- Department of Medical Oncology, Centre Léon Bérard, Lyon University, 69008 Lyon, France
- DOI
- https://doi.org/10.3390/cancers14112620
- Journal volume & issue
-
Vol. 14,
no. 11
p. 2620
Abstract
The national reference network NETSARC+ provides remote access to specialized diagnosis and the Multidisciplinary Tumour Board (MTB) to improve the management and survival of sarcoma patients in France. The IGéAS research program aims to assess the potential of this innovative organization to address geographical inequalities in cancer management. Using the IGéAS cohort built from the nationwide NETSARC+ database, the individual, clinical, and geographical determinants of the 3-year overall survival of sarcoma patients in France were analyzed. The survival analysis was focused on patients diagnosed in 2013 (n = 2281) to ensure sufficient hindsight to collect patient follow-up. Our study included patients with bone (16.8%), soft-tissue (69%), and visceral (14.2%) sarcomas, with a median age of 61.8 years. The overall survival was not associated with geographical variables after adjustment for individual and clinical factors. The lower survival in precarious population districts [HR 1.23, 95% CI 1.02 to 1.48] in comparison to wealthy metropolitan areas (HR = 1) found in univariable analysis was due to the worst clinical presentation at diagnosis of patients. The place of residence had no impact on sarcoma patients’ survival, in the context of the national organization driven by the reference network. Following previous findings, this suggests the ability of this organization to go through geographical barriers usually impeding the optimal management of cancer patients.
Keywords