Hippocampal gray matter volume in the long-term course after transient global amnesia

Mandy Pirlich; Cathleen Höfer; Christopher M. Weise; Anika Stockert; Angelika Thöne-Otto; Alexander Garthe; Stefan Schob; Joseph Classen; Karl-Titus Hoffmann; Dorothee Saur

NeuroImage: Clinical (Jan 2021)

Hippocampal gray matter volume in the long-term course after transient global amnesia

Mandy Pirlich,
Cathleen Höfer,
Christopher M. Weise,
Anika Stockert,
Angelika Thöne-Otto,
Alexander Garthe,
Stefan Schob,
Joseph Classen,
Karl-Titus Hoffmann,
Dorothee Saur

Affiliations

Mandy Pirlich: Department of Neurology (M.P., C.H., C.M.W., A.S., J.C., D.S.), Department of Neuroradiology (S.S., K.T.H.) and Department of Cognitive Neurology (A.T.O.), University of Leipzig Medical Center, Leipzig, Germany, German Center for Neurodegenerative Diseases, Dresden (A.G.), Germany
Cathleen Höfer: Department of Neurology (M.P., C.H., C.M.W., A.S., J.C., D.S.), Department of Neuroradiology (S.S., K.T.H.) and Department of Cognitive Neurology (A.T.O.), University of Leipzig Medical Center, Leipzig, Germany, German Center for Neurodegenerative Diseases, Dresden (A.G.), Germany
Christopher M. Weise: Department of Neurology, University of Halle Medical Center, Halle, Germany; Department of Neurology (M.P., C.H., C.M.W., A.S., J.C., D.S.), Department of Neuroradiology (S.S., K.T.H.) and Department of Cognitive Neurology (A.T.O.), University of Leipzig Medical Center, Leipzig, Germany, German Center for Neurodegenerative Diseases, Dresden (A.G.), Germany
Anika Stockert: Department of Neurology (M.P., C.H., C.M.W., A.S., J.C., D.S.), Department of Neuroradiology (S.S., K.T.H.) and Department of Cognitive Neurology (A.T.O.), University of Leipzig Medical Center, Leipzig, Germany, German Center for Neurodegenerative Diseases, Dresden (A.G.), Germany
Angelika Thöne-Otto: Department of Neurology (M.P., C.H., C.M.W., A.S., J.C., D.S.), Department of Neuroradiology (S.S., K.T.H.) and Department of Cognitive Neurology (A.T.O.), University of Leipzig Medical Center, Leipzig, Germany, German Center for Neurodegenerative Diseases, Dresden (A.G.), Germany
Alexander Garthe: Department of Neurology (M.P., C.H., C.M.W., A.S., J.C., D.S.), Department of Neuroradiology (S.S., K.T.H.) and Department of Cognitive Neurology (A.T.O.), University of Leipzig Medical Center, Leipzig, Germany, German Center for Neurodegenerative Diseases, Dresden (A.G.), Germany
Stefan Schob: Department of Neurology (M.P., C.H., C.M.W., A.S., J.C., D.S.), Department of Neuroradiology (S.S., K.T.H.) and Department of Cognitive Neurology (A.T.O.), University of Leipzig Medical Center, Leipzig, Germany, German Center for Neurodegenerative Diseases, Dresden (A.G.), Germany
Joseph Classen: Department of Neurology (M.P., C.H., C.M.W., A.S., J.C., D.S.), Department of Neuroradiology (S.S., K.T.H.) and Department of Cognitive Neurology (A.T.O.), University of Leipzig Medical Center, Leipzig, Germany, German Center for Neurodegenerative Diseases, Dresden (A.G.), Germany
Karl-Titus Hoffmann: Department of Neurology (M.P., C.H., C.M.W., A.S., J.C., D.S.), Department of Neuroradiology (S.S., K.T.H.) and Department of Cognitive Neurology (A.T.O.), University of Leipzig Medical Center, Leipzig, Germany, German Center for Neurodegenerative Diseases, Dresden (A.G.), Germany
Dorothee Saur: Department of Neurology (M.P., C.H., C.M.W., A.S., J.C., D.S.), Department of Neuroradiology (S.S., K.T.H.) and Department of Cognitive Neurology (A.T.O.), University of Leipzig Medical Center, Leipzig, Germany, German Center for Neurodegenerative Diseases, Dresden (A.G.), Germany; Corresponding author.

Journal volume & issue: Vol. 30
p. 102586

Abstract

Read online

Objective: In this retrospective, cross-sectional study we aimed to examine long-term memory deficits and gray matter volumes (GMV) in the hippocampus after transient global amnesia (TGA). Methods: 20 patients with a history of TGA (TGA+, mean 6.5 years after TGA) and 20 age-matched healthy controls (TGA-) underwent neurocognitive assessment (i.e. Mini-Mental State Examination (MMSE), visuospatial, verbal and episodic autobiographical memory and visuospatial learning/navigation [“human water maze”]) in combination with structural cerebral MRI. Voxel-based morphometry (VBM) was used to detect GMV in the hippocampus in TGA+ versus TGA-. Results: Besides slight differences in MMSE and visuo-spatial learning/navigation measured with a human water maze in TGA+ vs. TGA-, no other tests of visuo-spatial, verbal and autobiographical long-term memory differed between groups. VBM analyses yielded a statistically significant difference in bilateral hippocampal GMV with TGA+ compared to TGA- showing greater GMV in a region corresponding to bilateral CA1. However, none of the hippocampus-dependent cognitive measures correlated with hippocampal GMV. Conclusion: In the long-term course after TGA, only subtle neurocognitive deficits without microstructural damage of the hippocampus could be detected. Greater GMV in bilateral hippocampus in TGA+ vs. TGA- may indicate that TGA triggers hippocampal GMV increase rather than atrophy.

Published in NeuroImage: Clinical

ISSN: 2213-1582 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/neuroimage-clinical/

About the journal

Abstract

Keywords