Nature Communications (Nov 2022)
Predicting protein function and orientation on a gold nanoparticle surface using a residue-based affinity scale
Abstract
The orientation of proteins on nanoparticle surfaces is important to the nanoparticle’s fate in vivo. Here, the authors use competitive binding between protein variants to develop a residue-based affinity scale to develop a model for the binding and orientation of proteins on gold nanoparticles