USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components

Bo Ning; Wei Zhao; Chen Qian; Pinghua Liu; Qingtian Li; Wenyuan Li; Rong-Fu Wang

doi:10.1038/s41467-017-00301-4

Nature Communications (Aug 2017)

USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components

Bo Ning,
Wei Zhao,
Chen Qian,
Pinghua Liu,
Qingtian Li,
Wenyuan Li,
Rong-Fu Wang

Affiliations

Bo Ning: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Wei Zhao: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Chen Qian: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Pinghua Liu: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Qingtian Li: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Wenyuan Li: Center for Inflammation and Epigenetics, Houston Methodist Research Institute
Rong-Fu Wang: Center for Inflammation and Epigenetics, Houston Methodist Research Institute

DOI: https://doi.org/10.1038/s41467-017-00301-4
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

Read online

The ubiquitin-proteasome system regulates cellular reprogramming by degradation of key pluripotency factors. Here the authors report that the post-translational regulation of PRC1 components CBX4 and CBX6 by ubiquitination influences reprogramming.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal