Normogonadotropic ovarian insufficiency in adolescence (review of literature and clinical case)

Abstract

The objective of the review. Analysis of literature data related to the normogonadotropic ovarian insufficiency. Basic statements. The article presents a literature review and clinical case of normogonadotropic ovarian insufficiency in girls aged 16 years. The basic clinical-laboratory and genetic criteria are distinguished. We searched for published and unpublished studies using Pubmed as the search engine by the keywords: “normogonadotropic ovarian insufficiency”, “aromatase”, “molecular diagnosis”, “polycystic ovary syndrome”, “adolescents”, “clinical cases”, taking into consideration researches conducted for the last 15 years, citation review of relevant primary and review articles, conference abstracts, personal files, and contact with expert informants. The criterion for the selection of articles for the study was based on their close relevance to the topic, thus out of 256 analysed articles, the findings of the researchers covered in 34 articles were crucial. Because several features of polycystic ovary syndrome may be in evolution in adolescents, we suggest that only firm criteria should be used to make a diagnosis in adolescence: hyperandrogenism, oligomenorrhea and ovarian morphology. The most frequent clinical manifestations of aromatase deficiency of ovarian follicles are opsomenorrhea and androgen-dependent dermatopathy аnd genotype CYP19 ((TTTA)n polymorphism) — (TTTA)7(TTTA).

Keywords

• normogonadotropic ovarian insufficiency
• aromatase
• polycystic ovary syndrome
• adolescents