Chronic lymphocytic leukemia in the elderly: clinico-biological features, outcomes, and proposal of a prognostic model

Tycho Baumann; Julio Delgado; Rodrigo Santacruz; Alejandra Martínez-Trillos; Cristina Royo; Alba Navarro; Magda Pinyol; María Rozman; Arturo Pereira; Neus Villamor; Marta Aymerich; Cristina López; Anna Carrió; Emili Montserrat

doi:10.3324/haematol.2014.107326

Haematologica (Oct 2014)

Chronic lymphocytic leukemia in the elderly: clinico-biological features, outcomes, and proposal of a prognostic model

Tycho Baumann,
Julio Delgado,
Rodrigo Santacruz,
Alejandra Martínez-Trillos,
Cristina Royo,
Alba Navarro,
Magda Pinyol,
María Rozman,
Arturo Pereira,
Neus Villamor,
Marta Aymerich,
Cristina López,
Anna Carrió,
Emili Montserrat

Affiliations

Tycho Baumann: Institute of Hematology and Oncology, Department of Hematology, University of Barcelona, Barcelona, Spain;Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Julio Delgado: Institute of Hematology and Oncology, Department of Hematology, University of Barcelona, Barcelona, Spain
Rodrigo Santacruz: Institute of Hematology and Oncology, Department of Hematology, University of Barcelona, Barcelona, Spain
Alejandra Martínez-Trillos: Institute of Hematology and Oncology, Department of Hematology, University of Barcelona, Barcelona, Spain;Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Cristina Royo: Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Alba Navarro: Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Magda Pinyol: Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
María Rozman: Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Arturo Pereira: Department of Hemotherapy and Hemostasis; and Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
Neus Villamor: Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Marta Aymerich: Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Cristina López: Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Anna Carrió: Hematopathology Unit, Pathology Department, University of Barcelona, Barcelona, Spain
Emili Montserrat: Institute of Hematology and Oncology, Department of Hematology, University of Barcelona, Barcelona, Spain

DOI: https://doi.org/10.3324/haematol.2014.107326
Journal volume & issue: Vol. 99, no. 10

Abstract

Read online

We investigated the clinico-biological features, outcomes, and prognosis of 949 patients with chronic lymphocytic leukemia according to age. No biological differences (cytogenetics by fluorescent in situ hybridization, IGHV, ZAP-70, CD38, NOTCH1, SF3B1) were found across age groups. Elderly patients (>70 years; n=367) presented more frequently with advanced disease (Binet C/Rai III-IV: 10/12% versus 5/5%; P

Published in Haematologica

ISSN: 0390-6078 (Print); 1592-8721 (Online)
Publisher: Ferrata Storti Foundation
Country of publisher: Italy
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: http://www.haematologica.org

About the journal