Nature Communications (Jul 2022)
Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer
- Caterina Bartolacci,
- Cristina Andreani,
- Gonçalo Vale,
- Stefano Berto,
- Margherita Melegari,
- Anna Colleen Crouch,
- Dodge L. Baluya,
- George Kemble,
- Kurt Hodges,
- Jacqueline Starrett,
- Katerina Politi,
- Sandra L. Starnes,
- Daniele Lorenzini,
- Maria Gabriela Raso,
- Luisa M. Solis Soto,
- Carmen Behrens,
- Humam Kadara,
- Boning Gao,
- Ignacio I. Wistuba,
- John D. Minna,
- Jeffrey G. McDonald,
- Pier Paolo Scaglioni
Affiliations
- Caterina Bartolacci
- Department of Internal Medicine, University of Cincinnati College of Medicine
- Cristina Andreani
- Department of Internal Medicine, University of Cincinnati College of Medicine
- Gonçalo Vale
- Center for Human Nutrition, The University of Texas Southwestern Medical Center
- Stefano Berto
- Department of Neuroscience, The University of Texas Southwestern Medical Center
- Margherita Melegari
- Department of Internal Medicine, University of Cincinnati College of Medicine
- Anna Colleen Crouch
- Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center
- Dodge L. Baluya
- Tissue Imaging and Proteomics Laboratory, Washington State University
- George Kemble
- Sagimet Biosciences
- Kurt Hodges
- Department of Pathology, University of Cincinnati College of Medicine
- Jacqueline Starrett
- Yale Cancer Center, Yale School of Medicine
- Katerina Politi
- Yale Cancer Center, Yale School of Medicine
- Sandra L. Starnes
- Department of Surgery, Division of Thoracic Surgery, University of Cincinnati College of Medicine
- Daniele Lorenzini
- Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
- Maria Gabriela Raso
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Luisa M. Solis Soto
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Carmen Behrens
- Department of Thoracic H&N Medical Oncology, The University of Texas MD Anderson Cancer Center
- Humam Kadara
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Boning Gao
- Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center
- Ignacio I. Wistuba
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- John D. Minna
- Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center
- Jeffrey G. McDonald
- Center for Human Nutrition, The University of Texas Southwestern Medical Center
- Pier Paolo Scaglioni
- Department of Internal Medicine, University of Cincinnati College of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-31963-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Mutant KRAS (KM) is associated with poor prognosis in lung cancer and reported to promote lipid metabolism. Here, the authors show that fatty acid synthesis, which provides lipids to repair oxidized phospholipids through the FASN-Lands cycle axis, is a specific vulnerability for KM lung cancer.
