Synthesis of New Cisplatin Derivatives from Bile Acids

Barbara Seroka; Zenon Łotowski; Agnieszka Hryniewicka; Lucie Rárová; Rafal R. Sicinski; Aneta M. Tomkiel; Jacek W. Morzycki

doi:10.3390/molecules25030655

Molecules (Feb 2020)

Synthesis of New Cisplatin Derivatives from Bile Acids

Barbara Seroka,
Zenon Łotowski,
Agnieszka Hryniewicka,
Lucie Rárová,
Rafal R. Sicinski,
Aneta M. Tomkiel,
Jacek W. Morzycki

Affiliations

Barbara Seroka: Faculty of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland
Zenon Łotowski: Faculty of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland
Agnieszka Hryniewicka: Faculty of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland
Lucie Rárová: Laboratory of Growth Regulators, Faculty of Science, Palacký University, and Institute of Experimental Botany of the Czech Academy of Sciences, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic
Rafal R. Sicinski: Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland
Aneta M. Tomkiel: Faculty of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland
Jacek W. Morzycki: Faculty of Chemistry, University of Białystok, K. Ciołkowskiego 1K, 15-245 Białystok, Poland

DOI: https://doi.org/10.3390/molecules25030655
Journal volume & issue: Vol. 25, no. 3
p. 655

Abstract

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A series of bile acid derived 1,2- and 1,3-diamines as well as their platinum(II) complexes were designed and synthesized in hope to get a highly cytotoxic compound by the combination of two bioactive moieties. All complexes obtained were subjected to cytotoxicity assays in vitro and some hybrid molecules showed an expected activity.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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