Nature Communications (Jan 2020)
Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer
- Stanley Zhou,
- James R. Hawley,
- Fraser Soares,
- Giacomo Grillo,
- Mona Teng,
- Seyed Ali Madani Tonekaboni,
- Junjie Tony Hua,
- Ken J. Kron,
- Parisa Mazrooei,
- Musaddeque Ahmed,
- Christopher Arlidge,
- Hwa Young Yun,
- Julie Livingstone,
- Vincent Huang,
- Takafumi N. Yamaguchi,
- Shadrielle M. G. Espiritu,
- Yanyun Zhu,
- Tesa M. Severson,
- Alex Murison,
- Sarina Cameron,
- Wilbert Zwart,
- Theodorus van der Kwast,
- Trevor J. Pugh,
- Michael Fraser,
- Paul C. Boutros,
- Robert G. Bristow,
- Housheng Hansen He,
- Mathieu Lupien
Affiliations
- Stanley Zhou
- Princess Margaret Cancer Centre, University Health Network
- James R. Hawley
- Princess Margaret Cancer Centre, University Health Network
- Fraser Soares
- Princess Margaret Cancer Centre, University Health Network
- Giacomo Grillo
- Princess Margaret Cancer Centre, University Health Network
- Mona Teng
- Princess Margaret Cancer Centre, University Health Network
- Seyed Ali Madani Tonekaboni
- Princess Margaret Cancer Centre, University Health Network
- Junjie Tony Hua
- Princess Margaret Cancer Centre, University Health Network
- Ken J. Kron
- Princess Margaret Cancer Centre, University Health Network
- Parisa Mazrooei
- Princess Margaret Cancer Centre, University Health Network
- Musaddeque Ahmed
- Princess Margaret Cancer Centre, University Health Network
- Christopher Arlidge
- Princess Margaret Cancer Centre, University Health Network
- Hwa Young Yun
- Princess Margaret Cancer Centre, University Health Network
- Julie Livingstone
- Ontario Institute for Cancer Research
- Vincent Huang
- Ontario Institute for Cancer Research
- Takafumi N. Yamaguchi
- Ontario Institute for Cancer Research
- Shadrielle M. G. Espiritu
- Ontario Institute for Cancer Research
- Yanyun Zhu
- Division of Oncogenomics, Oncode Institute, the Netherlands Cancer Institute
- Tesa M. Severson
- Division of Oncogenomics, Oncode Institute, the Netherlands Cancer Institute
- Alex Murison
- Princess Margaret Cancer Centre, University Health Network
- Sarina Cameron
- Princess Margaret Cancer Centre, University Health Network
- Wilbert Zwart
- Division of Oncogenomics, Oncode Institute, the Netherlands Cancer Institute
- Theodorus van der Kwast
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Trevor J. Pugh
- Princess Margaret Cancer Centre, University Health Network
- Michael Fraser
- Ontario Institute for Cancer Research
- Paul C. Boutros
- Department of Medical Biophysics, University of Toronto
- Robert G. Bristow
- Princess Margaret Cancer Centre, University Health Network
- Housheng Hansen He
- Princess Margaret Cancer Centre, University Health Network
- Mathieu Lupien
- Princess Margaret Cancer Centre, University Health Network
- DOI
- https://doi.org/10.1038/s41467-020-14318-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
FOXA1 pioneer transcription factor is recurrently mutated in primary and metastatic prostate tumors. Here, authors identify a set of six cis-regulatory elements in the FOXA1 regulatory plexus harboring somatic SNVs in primary prostate tumors and characterize their role in regulating FOXA1 expression and prostate cancer cell growth.
