Nature Communications (Nov 2017)
Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma
- Moustafa Abdalla,
- Danh Tran-Thanh,
- Juan Moreno,
- Vladimir Iakovlev,
- Ranju Nair,
- Nisha Kanwar,
- Mohamed Abdalla,
- Jennifer P. Y. Lee,
- Jennifer Yin Yee Kwan,
- Thomas R. Cawthorn,
- Keisha Warren,
- Nona Arneson,
- Dong-Yu Wang,
- Natalie S. Fox,
- Bruce J. Youngson,
- Naomi A. Miller,
- Alexandra M. Easson,
- David McCready,
- Wey L. Leong,
- Paul C. Boutros,
- Susan J. Done
Affiliations
- Moustafa Abdalla
- Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network
- Danh Tran-Thanh
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Juan Moreno
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Vladimir Iakovlev
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Ranju Nair
- Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network
- Nisha Kanwar
- Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network
- Mohamed Abdalla
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Jennifer P. Y. Lee
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Jennifer Yin Yee Kwan
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Thomas R. Cawthorn
- Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network
- Keisha Warren
- Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network
- Nona Arneson
- Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network
- Dong-Yu Wang
- Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network
- Natalie S. Fox
- Department of Medical Biophysics, University of Toronto
- Bruce J. Youngson
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Naomi A. Miller
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Alexandra M. Easson
- Department of Surgical Oncology, Princess Margaret Cancer Center and University of Toronto
- David McCready
- Department of Surgical Oncology, Princess Margaret Cancer Center and University of Toronto
- Wey L. Leong
- Department of Surgical Oncology, Princess Margaret Cancer Center and University of Toronto
- Paul C. Boutros
- Department of Medical Biophysics, University of Toronto
- Susan J. Done
- Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network
- DOI
- https://doi.org/10.1038/s41467-017-01357-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Studying the spatial mutational and gene expression alterations in breast cancer could impact our understanding of breast cancer development. Here, the authors analyse a unique dataset of epithelial samples that highlight potential field cancerisation surrounding the primary tumour.
