Serum Vitamin D level in Jordanian patients with exfoliation syndrome and exfoliative glaucoma

Abstract

AIM: To compare the level of serum Vitamin D in patients with exfoliation syndrome(XFS)and exfoliative glaucoma(XFG)with that in control subjects.METHODS: Serum levels of 25-hydroxy Vitamin D(Vitamin D)were measured using liquid chromatography. Variables like age, sex and medical history of hypertension, diabetes mellitus and ischemic heart disease were reported.RESULTS: This study included a total of 55 patients with XFS/XFG and 60 control subjects. Patients with XFS/XFG were significantly older than control subjects(mean age: 71.8y vs 67.5y, P=0.002). Gender distribution was similar. The prevalence rates of diabetes, hypertension, and ischemic heart disease were not significantly different between the two groups. The mean of Vitamin D was 14.7 ng/mL for patients with XFS/XFG and 14.9 ng/mL for control subjects with no significant difference. Although Vitamin D level was lower in the XFS/XFG group but multivariate analysis did not show significant difference in Vitamin D deficiency between the two groups after adjusting for age, gender, and medical conditions.CONCLUSION: The outcomes of our study are different from those in the literature. Vitamin D levels were low in both the XFS/XFG group and the control group being lower in the first one but that difference was not statistically significant. XFS and Vitamin D deficiency share common associations with certain systemic diseases. Further studies with larger numbers are needed to elaborate more on these associations and to support further the controversial literature.

Keywords

• Vitamin D
• exfoliation syndrome
• exfoliative glaucoma
• exfoliative glaucoma