Biomarkers to target and silence stemness of breast cancer stem cell model: silencing MDR1 by siRNA

Yıldırım Gamze; Kars Meltem D.; Kars Gökhan; Kılıç Hamdi Ş.

doi:10.1515/tjb-2021-0275

Türk Biyokimya Dergisi (Mar 2022)

Biomarkers to target and silence stemness of breast cancer stem cell model: silencing MDR1 by siRNA

Yıldırım Gamze,
Kars Meltem D.,
Kars Gökhan,
Kılıç Hamdi Ş.

Affiliations

Yıldırım Gamze: Graduate School of Sciences, Department of Nanotechnology and Advanced Materials, Selçuk University, Konya, Turkey
Kars Meltem D.: Faculty of Engineering, Department of Biomedical Engineering, Necmettin Erbakan University, Konya, 42140, Turkey
Kars Gökhan: Faculty of Science, Department of Molecular Biology and Genetics, Necmettin Erbakan University, Konya, Turkey
Kılıç Hamdi Ş.: Faculty of Science, Department of Physics, Selçuk University, Konya, Turkey

DOI: https://doi.org/10.1515/tjb-2021-0275
Journal volume & issue: Vol. 47, no. 4
pp. 445 – 455

Abstract

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Aim of the study was to reveal new biomarker genes to target breast cancer stem-like cells (BCSC-like) and then sensitize BCSC-like cells to chemotherapy by silencing MDR1 gene found to be the most suitable target.

Published in Türk Biyokimya Dergisi

ISSN: 1303-829X (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.degruyter.com/journal/key/tjb/html

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