In Silico Toxicological Assessment and Efficacy of Activated Carbon Derived from Low-Quality Face Tissues for Eosin Dye Adsorption

Abstract

Eosin dye is an efficient qualitative and quantitative chemical through various scientific and biological uses but it was demonstrated as a lethal substance to animal or human lung, liver, eye, kidney, Central Nerve System (CNS) and parts of gastrointestinal system. In many published studies, it removed via clay/carbon composite, lemon peel, or fly ash adsorption beside oxidation, filtration, photocatalysis, ion exchange, sonochemistry, nanotechnology, and others. Here, is another attempt to prepare an activated carbon from carbon-based material (low quality face tissue) where its capacity was determined by toxic anionic dye (Eosin B) – spectroscopic investigation. In this attempt, Eosin B showed an excellent removal and adsorption capacity starting from first 5 mL eluted from this prepared adsorbent. Removal of Eosin is important to human and environment where present In Silico study confirmed that Eosin B was safe to embryo or foetus health (during pregnancy) , Cardio- topic including: Arrhythmia, Cardiac Failure, Heart Block, hERG Toxicity, Hypertension, and Myocardial Infarction, toxic to avian with high Rat Acute Toxicity (LD50) lowest probability of lung, prostate, and renal cell lines even with its water solubility in aqua environment, Yes response towards P-glycoprotein substrate or multidrug resistance (MDR1) function in cancer pharmacotherapy. Also, Eosin B had BBB or CNS permeability as well as fish (Minnow) toxicity. It is safe for Renal OCT2 substrate, besides hERG I & II inhibitors, Hepatotoxicity, and skin sensitization, Cytochromes P450 under testing. Therefore, Eosin B is structurally toxic to human and environment in short – or long – term period.

Keywords

• Activated carbon
• Face tissue
• Eosin
• Pollution
• Aqueous solution