A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine

Joanes Grandjean; Alberto Corcoba; Martin C. Kahn; A. Louise Upton; Evan S. Deneris; Erich Seifritz; Fritjof Helmchen; Isabelle M. Mansuy; Edward O. Mann; Markus Rudin; Bechara J. Saab

doi:10.1038/s41467-018-08256-w

Nature Communications (Jan 2019)

A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine

Joanes Grandjean,
Alberto Corcoba,
Martin C. Kahn,
A. Louise Upton,
Evan S. Deneris,
Erich Seifritz,
Fritjof Helmchen,
Isabelle M. Mansuy,
Edward O. Mann,
Markus Rudin,
Bechara J. Saab

Affiliations

Joanes Grandjean: Singapore Bioimaging Consortium, Agency for Science Technology and Research
Alberto Corcoba: Center for Psychiatric Neuroscience, University of Lausanne
Martin C. Kahn: Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich Hospital for Psychiatry
A. Louise Upton: Department of Physiology, Anatomy and Genetics, University of Oxford
Evan S. Deneris: Department of Neurosciences, Case Western Reserve University School of Medicine
Erich Seifritz: Neuroscience Center Zurich
Fritjof Helmchen: Neuroscience Center Zurich
Isabelle M. Mansuy: Laboratory of Neuroepigenetics, Brain Research Institute, Medical Faculty of the University of Zürich, Institute for Neuroscience, Department of Health Science and Technology of ETH Zürich
Edward O. Mann: Department of Physiology, Anatomy and Genetics, University of Oxford
Markus Rudin: Neuroscience Center Zurich
Bechara J. Saab: Neuroscience Center Zurich

DOI: https://doi.org/10.1038/s41467-018-08256-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

Read online

Serotonin is released throughout the brain from diverse projections of neurons in the dorsal raphe nucleus. Here, the authors use optogenetics and fMRI mediated mapping of the mouse brain-wide serotonin network in response to acute stress and treatment with SSRI.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal