P-63 TRENDS IN HOSPITALIZATION AND MORTALITY IN HOSPITALIZED PATIENTS WITH ALCOHOLIC HEPATITIS IN CHILE

Abstract

Introduction: Hospitalizations (H) and mortality by alcoholic hepatitis (AH) have increased in Europe and North America. In Chile we do not have published data. Objectives: To describe the trend in H and mortality of hospitalized patients with AH in Chile. Methods: Descriptive analysis of combination of cross-sections and regression models (STATA 15). Population data from MINSAL-DEIS 2001-2018 hospital discharge databases (HD) were used. HD by AH were identified by ICD-10 code K701. Results: Between 2001-2018 there were 5,678 HD per AH. Average age 50 years. The rate of HD per AH per million inhabitants increased from 12.8 in 2001 to 18.5 in 2018 (44%). A linear estimate suggests that the rate increases by 0.55 points per year. In the population of 20-40 years it stands out that in women it increased by 64%. The only group where the rate of HD per AH increase steadily over time (in the rest the increase was less and less). The proportion by sex remained stable in 83% men and 17% women. In both sexes, 10% HD deceased, although in men a clear upward trend is observed (+0.32% annually, with a minimum of 6.5% HD in 2001 and a maximum of 15.3% HD in 2017), while in women the upward trend shows fluctuations. Conclusions: In Chile in recent years there has been an increase in HD by AH. This increased incidence is reflected in higher mortality in patients hospitalized for AH. The increase in HD was more stable among women aged 20-40 years.