The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity

Alexandra Santanach; Enrique Blanco; Hua Jiang; Kelly R. Molloy; Miriam Sansó; John LaCava; Lluis Morey; Luciano Di Croce

doi:10.1038/s41467-017-01464-w

Nature Communications (Nov 2017)

The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity

Alexandra Santanach,
Enrique Blanco,
Hua Jiang,
Kelly R. Molloy,
Miriam Sansó,
John LaCava,
Lluis Morey,
Luciano Di Croce

Affiliations

Alexandra Santanach: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Enrique Blanco: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Hua Jiang: Laboratory of Cellular and Structural Biology, The Rockefeller University
Kelly R. Molloy: Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University
Miriam Sansó: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
John LaCava: Laboratory of Cellular and Structural Biology, The Rockefeller University
Lluis Morey: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Luciano Di Croce: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology

DOI: https://doi.org/10.1038/s41467-017-01464-w
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

Read online

In mammals, five different CBX proteins can be part of Polycomb repressive complex 1 (PRC1). Here, the authors provide evidence that CBX6 plays an essential role in regulating pluripotency in embryonic stem cells and that CBX6 functions as part of both canonical and non-canonical PRC1 complexes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal