MERS-CoV‒Specific T-Cell Responses in Camels after Single MVA-MERS-S Vaccination

Abstract

We developed an ELISPOT assay for evaluating Middle East respiratory syndrome coronavirus (MERS-CoV)‒specific T-cell responses in dromedary camels. After single modified vaccinia virus Ankara-MERS-S vaccination, seropositive camels showed increased levels of MERS-CoV‒specific T cells and antibodies, indicating suitability of camel vaccinations in disease-endemic areas as a promising approach to control infection.

Keywords

• MERS-CoV
• Middle East respiratory syndrome coronavirus
• coronavirus
• viruses
• dromedary camels
• T-cell responses