Recent Biomimetic and Organocatalytic Syntheses of ?-Tocopherol

Antoinette Chougnet; Kegang Liu; Wolf-D. Woggon

doi:10.2533/chimia.2010.303

CHIMIA (May 2010)

Recent Biomimetic and Organocatalytic Syntheses of ?-Tocopherol

Antoinette Chougnet,
Kegang Liu,
Wolf-D. Woggon

Affiliations

Antoinette Chougnet: Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel
Kegang Liu: Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel
Wolf-D. Woggon: Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel;, Email: [email protected]

DOI: https://doi.org/10.2533/chimia.2010.303
Journal volume & issue: Vol. 64, no. 5

Abstract

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We report here on our efforts to develop new strategies for the synthesis of ?-tocopherol, the biologically most significant member of the vitamin E family. This review comprises five new methods to generate the chiral chromane of ?-tocopherol with overall up to 29% yield from commercially available material and up to 94% de.

Published in CHIMIA

ISSN: 0009-4293 (Print); 2673-2424 (Online)
Publisher: Swiss Chemical Society
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://chimia.ch

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