The evaluation of PIK3CA gene variation and serum PI3K level in breast cancer risk and prognosis in Turkish population

Abstract

The PI3K (Phosphatidylinositol 3-kinase) is the member of lipid kinase family that plays important roles in tumorigenesis, cancer development and cell proliferation. In our study, we aimed to investigate the relationships between breast cancer risk and prognosis with PIK3CA rs6443624 (C>A) intron region gene polymorphism and serum PI3K levels.

Keywords

• apoptosis
• breast cancer
• phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca)
• serum level
• single nucleotide polymorphism (snp)
• apoptoz
• meme kanseri
• fosfatidilinozitol-4,5-bifosfat 3-kinaz katalitik alt birim alfa (pik3ca)
• serum düzeyi
• tek nükleotid polimorfizmi (snp)