Direct structure determination of vemurafenib polymorphism from compact spherulites using 3D electron diffraction

Abstract

The spherulite morphology is common among crystalline materials and melt-crystallized products, however, the structural determination of spherulites by X-ray diffraction remains difficult due to their polycrystalline nature. Here, the authors report the direct structure determination of the polymorphism of vemurafenib in compact spherulite form using 3D electron diffraction.