Nature Communications (Mar 2023)

Rapid protection induced by a single-shot Lassa vaccine in male cynomolgus monkeys

  • Mathieu Mateo,
  • Stéphanie Reynard,
  • Natalia Pietrosemoli,
  • Emeline Perthame,
  • Alexandra Journeaux,
  • Kodie Noy,
  • Clara Germain,
  • Xavier Carnec,
  • Caroline Picard,
  • Virginie Borges-Cardoso,
  • Jimmy Hortion,
  • Hélène Lopez-Maestre,
  • Pierrick Regnard,
  • Lyne Fellmann,
  • Audrey Vallve,
  • Stéphane Barron,
  • Ophélie Jourjon,
  • Orianne Lacroix,
  • Aurélie Duthey,
  • Manon Dirheimer,
  • Maïlys Daniau,
  • Catherine Legras-Lachuer,
  • Caroline Carbonnelle,
  • Hervé Raoul,
  • Frédéric Tangy,
  • Sylvain Baize

DOI
https://doi.org/10.1038/s41467-023-37050-6
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 18

Abstract

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Lassa virus vaccination is impeded by the limited capacity of vaccine candidates to induce rapid protection. In this study, the authors found that a single shot of a measles-based Lassa vaccine protected nonhuman primates 16 or 8 days after vaccination.