The impact of Transcranial Magnetic Stimulation (TMS) on seizure course in people with and without epilepsy

Serena Pang; Sasha D'Ambrosio; Giulia Battaglia; Diego Jiménez-Jiménez; Marco Perulli; Katri Silvennoinen; Sara Zagaglia; Sanjay M. Sisodiya; Simona Balestrini

Clinical Neurophysiology Practice (Jan 2022)

The impact of Transcranial Magnetic Stimulation (TMS) on seizure course in people with and without epilepsy

Serena Pang,
Sasha D'Ambrosio,
Giulia Battaglia,
Diego Jiménez-Jiménez,
Marco Perulli,
Katri Silvennoinen,
Sara Zagaglia,
Sanjay M. Sisodiya,
Simona Balestrini

Affiliations

Serena Pang: Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK
Sasha D'Ambrosio: Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK
Giulia Battaglia: Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK
Diego Jiménez-Jiménez: Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK; School of Medicine, Universidad San Francisco de Quito, Quito, Ecuador
Marco Perulli: Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK; Child Neurology and Psychiatry Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Department of Neuroscience, Catholic University Of The Sacred Heart, Rome, Italy
Katri Silvennoinen: Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK
Sara Zagaglia: Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK
Sanjay M. Sisodiya: Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK
Simona Balestrini: Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, and Epilepsy Society, Chalfont-St-Peter, Bucks, UK; Neuroscience Department, Children's Hospital Meyer-University of Florence, Florence, Italy; Corresponding author at: Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.

Journal volume & issue: Vol. 7
pp. 174 – 182

Abstract

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Objective: To elucidate the effects of single and paired-pulse TMS on seizure activity at electrographic and clinical levels in people with and without epilepsy. Methods: A cohort of 35 people with epilepsy, two people with alternating hemiplegia of childhood (AHC) with no epilepsy, and 16 healthy individuals underwent single or paired-pulse TMS combined with EEG. Clinical records and subject interviews were used to examine seizure frequency four weeks before and after TMS. Results: There were no significant differences in seizure frequency in any subject after TMS exposure. There was no occurrence of seizures in healthy individuals, and no worsening of hemiplegic attacks in people with AHC. Conclusions: No significant changes in seizure activity were found before or after TMS. Significance: This study adds evidence on the safety of TMS in people with and without epilepsy with follow-up of four weeks after TMS.

Published in Clinical Neurophysiology Practice

ISSN: 2467-981X (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/clinical-neurophysiology-practice

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