Diabetes, Metabolic Syndrome and Obesity (Sep 2023)
Correlation Between Hemoglobin Levels and Polycystic Ovary Syndrome Metabolic Disorder
Abstract
Ling-Xia Ha,1 Yu-Dong Du,2,3 Xiao-Xiao Qu,2 Jin-Juan Wang2 1Reproductive Medicine Center, General Hospital of Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia, 750004, People’s Republic of China; 2Ningxia Medical University, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, People’s Republic of China; 3Department of Reproductive Medicine, Luoyang Maternal and Child Health Hospital, Luoyang, Henan, 471000, People’s Republic of ChinaCorrespondence: Ling-Xia Ha, Reproductive Medicine Center, General Hospital of Ningxia Medical University, No. 804 of Shengli Road, Xingqing District, Yinchuan, 750004, People’s Republic of China, Tel +86 951 6744033 ; +86 13629500990, Fax +86 951 6743891, Email [email protected]: The purpose of this study was to explore the relationship between hemoglobin levels and metabolic disorders in patients with PCOS.Methods: A total of 573 patients were selected, based on the hemoglobin level; 342 patients with PCOS were divided into two groups as follows: Group A (normal Hb group, n = 269) and Group B (high Hb group, n = 73); 231 non-PCOS patients were divided into two groups as follows: Group C (normal Hb group, n = 199), and Group D (high Hb group, n = 32). The general information, glucose and lipid metabolism indicators, and uric acid levels of all patients were compiled for data analysis.Results: (1) Hb, HGB concentration in mean red blood cells and RDW in PCOS patients were higher than those in non-PCOS patients, and MCV was lower than that in non-PCOS patients (P < 0.05); (2) Compared with Group A, patients in Group B had higher BMI, Hb, 2-hPG, FINS, 2-hINS, HOMA-IR, LDL-C, and uric acid levels while the QUICKI was lower; in Group C, the age, FSH, HDL-C, and LDL-C were higher, and AMH, BMI, T, TG, and uric acid level were lower (P< 0.05); compared with Group D, AMH, BMI, FINS, HOMA-IR, TG, uric acid level increased, while age, FSH, and QUICKI decreased in Group B; and Hb and T decreased in Group C (P< 0.05); (3) Pearson’s correlation analysis indicated that Hb in PCOS patients was positively correlated with BMI, FPG, 2-hPG, FINS, 2-hINS, and HOMA-IR, and negatively correlated with the QUICKI (P< 0.05); (4) Multi-factor logistic regression analysis suggested that the high Hb level in PCOS patients was an independent risk factor of IR (P< 0.05).Conclusion: Hb level in patients with PCOS was associated with BMI and glucose metabolism indicators; a high Hb level may be an independent risk factor for IR.Keywords: hemoglobin, insulin resistance, metabolic disorder, polycystic ovary syndrome
