Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence

Ioana Olan; Aled J. Parry; Stefan Schoenfelder; Masako Narita; Yoko Ito; Adelyne S. L. Chan; Guy St.C. Slater; Dóra Bihary; Masashige Bando; Katsuhiko Shirahige; Hiroshi Kimura; Shamith A. Samarajiwa; Peter Fraser; Masashi Narita

doi:10.1038/s41467-020-19878-4

Nature Communications (Nov 2020)

Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence

Ioana Olan,
Aled J. Parry,
Stefan Schoenfelder,
Masako Narita,
Yoko Ito,
Adelyne S. L. Chan,
Guy St.C. Slater,
Dóra Bihary,
Masashige Bando,
Katsuhiko Shirahige,
Hiroshi Kimura,
Shamith A. Samarajiwa,
Peter Fraser,
Masashi Narita

Affiliations

Ioana Olan: Cancer Research UK Cambridge Institute, University of Cambridge
Aled J. Parry: Cancer Research UK Cambridge Institute, University of Cambridge
Stefan Schoenfelder: Epigenetics Programme, The Babraham Institute, Babraham Research Campus
Masako Narita: Cancer Research UK Cambridge Institute, University of Cambridge
Yoko Ito: Cancer Research UK Cambridge Institute, University of Cambridge
Adelyne S. L. Chan: Cancer Research UK Cambridge Institute, University of Cambridge
Guy St.C. Slater: Cancer Research UK Cambridge Institute, University of Cambridge
Dóra Bihary: MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge Biomedical Campus
Masashige Bando: Laboratory of Genome Structure and Function, Institute of Molecular and Cellular Biosciences, The University of Tokyo
Katsuhiko Shirahige: Laboratory of Genome Structure and Function, Institute of Molecular and Cellular Biosciences, The University of Tokyo
Hiroshi Kimura: Cell Biology Centre, Institute of Innovative Research, Tokyo Institute of Technology
Shamith A. Samarajiwa: MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge Biomedical Campus
Peter Fraser: Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus
Masashi Narita: Cancer Research UK Cambridge Institute, University of Cambridge

DOI: https://doi.org/10.1038/s41467-020-19878-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Senescence is a state of stable proliferative arrest. Here, the authors perform Hi-C analysis on oncogenic RAS-induced senescence in human fibroblasts and characterize the changes in the 3D genome folding associated with the senescence-specific gene expression profile, which are mediated in part through cohesin redistribution on chromatin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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