RG/RGG repeats in the C. elegans homologs of Nucleolin and GAR1 contribute to sub-nucleolar phase separation

Emily L. Spaulding; Alexis M. Feidler; Lio A. Cook; Dustin L. Updike

doi:10.1038/s41467-022-34225-5

Nature Communications (Nov 2022)

RG/RGG repeats in the C. elegans homologs of Nucleolin and GAR1 contribute to sub-nucleolar phase separation

Emily L. Spaulding,
Alexis M. Feidler,
Lio A. Cook,
Dustin L. Updike

Affiliations

Emily L. Spaulding: Davis Center for Regenerative Biology and Medicine, The Mount Desert Island Biological Laboratory
Alexis M. Feidler: Davis Center for Regenerative Biology and Medicine, The Mount Desert Island Biological Laboratory
Lio A. Cook: Davis Center for Regenerative Biology and Medicine, The Mount Desert Island Biological Laboratory
Dustin L. Updike: Davis Center for Regenerative Biology and Medicine, The Mount Desert Island Biological Laboratory

DOI: https://doi.org/10.1038/s41467-022-34225-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Spaulding et al. survey RG/RGG repeats in C. elegans and identify the homologs of Nucleolin (NUCL-1) and GAR1 (GARR-1). RG/RGG repeats are dispensable for nucleolar accumulation but critical for sub-nucleolar phase separation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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