Defining decision thresholds for judgments on health benefits and harms using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Evidence to Decision (EtD) frameworks: a protocol for a randomised methodological study (GRADE-THRESHOLD)

• Pablo Alonso-Coello,
• Lawrence Mbuagbaw,
• Elena Parmelli,
• Feng Xie,
• Holger J Schünemann,
• Antonio Bognanni,
• Nancy Santesso,
• Wojtek Wiercioch,
• Elie A Akl,
• Thomas Piggott,
• Uwe Siebert,
• Ilse M Verstijnen,
• Andrea J Darzi,
• Jan L Brozek,
• Gian Paolo Morgano,
• Zuleika Saz-Parkinson

Affiliations

Pablo Alonso-Coello

senior researcher

Lawrence Mbuagbaw

Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada

Elena Parmelli

5 Department of Epidemiology, Lazio Regional Health Service - ASL Roma 1, Rome, Italy

Feng Xie

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada

Holger J Schünemann

Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada

Antonio Bognanni

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada

Nancy Santesso

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada

Wojtek Wiercioch

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada

Elie A Akl

professor

Thomas Piggott

Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada

Uwe Siebert

Department of Health Policy and Management, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA

Ilse M Verstijnen

Dutch National Health Care Institute (ZIN) (formerly named CVZ), Diemen, The Netherlands

Andrea J Darzi

methodologist

Jan L Brozek

lecturer in medicine

Gian Paolo Morgano

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada

Zuleika Saz-Parkinson

European Commission Joint Research Centre, Ispra, Italy