Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys

Abbas Dehnadi; A. Benedict Cosimi; Rex Neal Smith; Xiangen Li; José L. Alonso; Terry K. Means; M. Amin Arnaout

doi:10.1038/ncomms13899

Nature Communications (Jan 2017)

Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys

Abbas Dehnadi,
A. Benedict Cosimi,
Rex Neal Smith,
Xiangen Li,
José L. Alonso,
Terry K. Means,
M. Amin Arnaout

Affiliations

Abbas Dehnadi: Division of Transplant Surgery, Department of Surgery, Massachusetts General Hospital
A. Benedict Cosimi: Division of Transplant Surgery, Department of Surgery, Massachusetts General Hospital
Rex Neal Smith: Harvard Medical School
Xiangen Li: Harvard Medical School
José L. Alonso: Harvard Medical School
Terry K. Means: Harvard Medical School
M. Amin Arnaout: Harvard Medical School

DOI: https://doi.org/10.1038/ncomms13899
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Acute kidney injury can progress to chronic kidney disease. Here Dehnadiet al. develop a post-ischaemic chronic kidney disease model in cynomolgus monkeys and show that prophylactic inhibition of CD11b/CD18 leukocyte receptor via a monoclonal antibody inhibits progression of kidney disease and fibrosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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