Emerging Microbes and Infections (Jan 2016)
A fatal yellow fever virus infection in China: description and lessons
- Zhihai Chen,
- Lin Liu,
- Yanning Lv,
- Wei Zhang,
- Jiandong Li,
- Yi Zhang,
- Tian Di,
- Shuo Zhang,
- Jingyuan Liu,
- Jie Li,
- Jing Qu,
- Wenhao Hua,
- Chuan Li,
- Peng Wang,
- Quanfu Zhang,
- Yanli Xu,
- Rongmeng Jiang,
- Qin Wang,
- Lijuan Chen,
- Shiwen Wang,
- Xinghuo Pang,
- Mifang Liang,
- Xuejun Ma,
- Xingwang Li,
- Quanyi Wang,
- Fujie Zhang,
- Dexin Li
Affiliations
- Zhihai Chen
- The National Clinical Key Department of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Lin Liu
- National Health and Family Planning Commission of the People's Republic of China Key Laboratory for Medical Virology, Department of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Yanning Lv
- Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing 100013, China
- Wei Zhang
- The National Clinical Key Department of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Jiandong Li
- National Health and Family Planning Commission of the People's Republic of China Key Laboratory for Medical Virology, Department of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Yi Zhang
- National Health and Family Planning Commission of the People's Republic of China Key Laboratory for Medical Virology, Department of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Tian Di
- The National Clinical Key Department of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Shuo Zhang
- National Health and Family Planning Commission of the People's Republic of China Key Laboratory for Medical Virology, Department of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Jingyuan Liu
- The National Clinical Key Department of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Jie Li
- Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing 100013, China
- Jing Qu
- National Health and Family Planning Commission of the People's Republic of China Key Laboratory for Medical Virology, Department of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Wenhao Hua
- The National Clinical Key Department of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Chuan Li
- National Health and Family Planning Commission of the People's Republic of China Key Laboratory for Medical Virology, Department of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Peng Wang
- The National Clinical Key Department of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Quanfu Zhang
- National Health and Family Planning Commission of the People's Republic of China Key Laboratory for Medical Virology, Department of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Yanli Xu
- The National Clinical Key Department of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Rongmeng Jiang
- The National Clinical Key Department of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Qin Wang
- National Health and Family Planning Commission of the People's Republic of China Key Laboratory for Medical Virology, Department of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Lijuan Chen
- Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing 100013, China
- Shiwen Wang
- National Health and Family Planning Commission of the People's Republic of China Key Laboratory for Medical Virology, Department of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Xinghuo Pang
- Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing 100013, China
- Mifang Liang
- National Health and Family Planning Commission of the People's Republic of China Key Laboratory for Medical Virology, Department of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Xuejun Ma
- National Health and Family Planning Commission of the People's Republic of China Key Laboratory for Medical Virology, Department of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- Xingwang Li
- The National Clinical Key Department of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Quanyi Wang
- Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing 100013, China
- Fujie Zhang
- The National Clinical Key Department of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
- Dexin Li
- National Health and Family Planning Commission of the People's Republic of China Key Laboratory for Medical Virology, Department of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
- DOI
- https://doi.org/10.1038/emi.2016.89
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 8
Abstract
Yellow fever (YF) is a viral disease endemic to the tropical regions of Africa and South America. An outbreak of YF has been occurring in Angola, since the beginning of 2016. In March 2016, a 32-year-old Chinese man who returned from Angola was hospitalized and diagnosed with the first case of imported YF in China. Clinical observations, blood viral RNA detection, serological testing and treatments for the patient were performed daily. The virus was isolated in Vero cells, and the complete viral genome was sequenced and analyzed using the next-generation genomic sequencing platform. The patient presented with hemorrhagic fever, jaundice and oliguria at day 3 after onset, which rapidly progressed to multisystem organ failure with extremely elevated liver, pancreatic and myocardial enzymes. The patient died despite the intensive supportive treatments that were performed. A liver biopsy showed severe and multilobular necrosis. Viral RNA was detectable throughout the clinical course of the disease. Whole-genomic sequence analysis revealed that the virus belongs to the Angola71 genotype. Although the virus has been circulating in Angola for 45 years, only 14 amino-acid substitutions and no amino-acid changes were observed in the membrane and envelope proteins compared with the virus collected in 1971. The presence of this imported YF case in China indicated that with the increase in business travel among countries, YF outbreaks in Africa can lead to the international spread of the disease. The production and use of YF vaccines is, therefore, an urgent issue.
Keywords
