Detection of giant cytoplasmic inclusions in a pediatric patient with recurrent infections: a case report

Abstract

Giant inclusions in leukocytes is a common feature that can be observed in some infections but can be also related to rare genetic disorders such as Chédiak-Higashi syndrome (CHS). A differential diagnosis between these groups of diseases has to be performed using specific genetic tests. Clinical and pathological history is relevant for a diagnostic orientation due to the difficulty and specificity of the diagnostic confirmation.

Keywords

• giant inclusions
• chédiak-higashi
• genetic disorder