α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation

Mariana Pavel; So Jung Park; Rebecca A. Frake; Sung Min Son; Marco M. Manni; Carla F. Bento; Maurizio Renna; Thomas Ricketts; Fiona M. Menzies; Radu Tanasa; David C. Rubinsztein

doi:10.1038/s41467-021-21882-1

Nature Communications (Mar 2021)

α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation

Mariana Pavel,
So Jung Park,
Rebecca A. Frake,
Sung Min Son,
Marco M. Manni,
Carla F. Bento,
Maurizio Renna,
Thomas Ricketts,
Fiona M. Menzies,
Radu Tanasa,
David C. Rubinsztein

Affiliations

Mariana Pavel: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building
So Jung Park: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building
Rebecca A. Frake: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building
Sung Min Son: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building
Marco M. Manni: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building
Carla F. Bento: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building
Maurizio Renna: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building
Thomas Ricketts: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building
Fiona M. Menzies: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building
Radu Tanasa: Department of Physics, Alexandru Ioan Cuza University of Iasi
David C. Rubinsztein: Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building

DOI: https://doi.org/10.1038/s41467-021-21882-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 21

Abstract

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Autophagy regulates multiple pathways including YAP/TAZ of the Hippo pathway, but precise mechanisms are unclear as autophagy may either activate or inhibit YAP/TAZ. Here, the authors show that autophagy can either activate or regulate YAP/TAZ via dynamic negative feedback loops involving alpha-catenin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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