P7.11 PREDICTIVE VALUE OF ENDOTHEL DYSFUNCTION ASSESSED BY FLOW MEDIATED VASODILATATION AND ARTERIAL STIFFNESS PARAMETERES IN THROMBOTIC EVENTS OF PRIMARY ANTIPHOSPHOLIPID SYNDROME

Abstract

Primary antiphosphplipid sydrome (APS) is characterized by recurrent arterial or venous thrombosis and/or fetal loss in the presence of antiphospholipd antibodies. The authors in a longitudinal (2005–2015) follow-up study examined how the angiological and metabolic parameters have changed during the follow up. The aim was to define if there is any association with the latter thrombotic events and the changing of examined parameters and if the parameters have any predictive values in APS specific events. In 2005 49 primary APS patient were enrolled. In 2015 26 patient participated in the follow up measurments, but we obtained clinical history from all of the patients. Endothel function was decribed by flow mediated vasodilatation (FMD), stiffness parameters (augmentation index, pulse wave velocity), carotis intima-media thickness (cIMT) were examined, and metabolic parameteres were also determined. During the follow-up 28 patient suffered thromboembolic events, in 21 patients did not have any kind of thrmboembolic events. In the trombotic group the onset cIMT was significantly higher (0,73 mm vs.0,63; p=0,014) than in patients without thrombotic events. As for the other onset angiological parameters there were no significant difference between the thrombotic and non-thrombotic group. In the thrombotic group significantly more patient smoked (p=0,015). In the non-thrmbotic group the endothel function significantly improved (p=0,019) while in the trombotic group the cIMT significantly increased (p=0,05) during the 10 year follow-up. The improvement of endothel function with pharmalogical and non –pharmacological meaures has positive clinical benefit. The abnormal stiffness parameters do not correlate with the clinical outcome.