Molecular genetic foundation of a sex-linked tailless trait in Hongshan chicken by whole genome data analysis

Anqi Chen; Qiong Wang; Xiurong Zhao; Gang Wang; Xinye Zhang; Xufang Ren; Yalan Zhang; Xue Cheng; Xiaofan Yu; Xiaohan Mei; Huie Wang; Menghan Guo; Xiaoyu Jiang; Guozhen Wei; Xue Wang; Runshen Jiang; Xing Guo; Zhonghua Ning; Lujiang Qu

Poultry Science (Jun 2024)

Molecular genetic foundation of a sex-linked tailless trait in Hongshan chicken by whole genome data analysis

Anqi Chen,
Qiong Wang,
Xiurong Zhao,
Gang Wang,
Xinye Zhang,
Xufang Ren,
Yalan Zhang,
Xue Cheng,
Xiaofan Yu,
Xiaohan Mei,
Huie Wang,
Menghan Guo,
Xiaoyu Jiang,
Guozhen Wei,
Xue Wang,
Runshen Jiang,
Xing Guo,
Zhonghua Ning,
Lujiang Qu

Affiliations

Anqi Chen: National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Qiong Wang: National Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China
Xiurong Zhao: National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Gang Wang: National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Xinye Zhang: National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Xufang Ren: National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Yalan Zhang: National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Xue Cheng: National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Xiaofan Yu: National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Xiaohan Mei: National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Huie Wang: Xinjiang Production and Construction Corps, Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Tarim University, Alar 843300, China
Menghan Guo: National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Xiaoyu Jiang: National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Guozhen Wei: Qingliu Animal Husbandry, Veterinary and Aquatic Products Center, Sanming, China
Xue Wang: VVBK Animal Medical Diagnostic Technology (Beijing) Co., Ltd, Beijing, China
Runshen Jiang: College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
Xing Guo: College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
Zhonghua Ning: National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Lujiang Qu: National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China; Xinjiang Production and Construction Corps, Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Tarim University, Alar 843300, China; Corresponding author:

Journal volume & issue: Vol. 103, no. 6
p. 103685

Abstract

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ABSTRACT: As a Chinese local chicken breed, Hongshan chickens have 2 kinds of tail feather phenotypes, normal and taillessness. Our previous studies showed that taillessness was a sex-linked dominant trait. Abnormal development of the tail vertebrae could be explained this phenomenon in some chicken breeds. However, the number of caudal vertebrae in rumpless Hongshan chickens was normal, so rumplessness in Hongshan chicken was not related to the development of the caudal vertebrae. Afterwards, we found that rumplessness in Hongshan was due to abnormal development of tail feather rather than abnormal development of caudal vertebrae. In order to understand the genetic foundation of the rumplessness of Hongshan chickens, we compared and reanalyzed 2 sets of data in normal and rumpless Hongshan chickens from our previous studies. By joint analysis of genome-wide selection signature analysis and genome-wide association approach, we found that 1 overlapping gene (EDIL3) and 16 peak genes (ENSGALG00000051843, ENSGALG00000053498, ENSGALG00000054800, KIF27, PTPRD, ENSGALG00000047579, ENSGALG00000041052, ARHGEF28, CAMK4, SERINC5, ENSGALG00000050776, ERCC8, MCC, ADAMTS19, ENSGALG00000053322, CHRNA8) located on the Z chromosome was associated with the rumpless trait. The results of this study furtherly revealed the molecular mechanism of the rumpless trait in Hongshan chickens, and identified the candidate genes associated with this trait. Our results will help to improve the shape of chicken tail feathers and to rise individual economic value in some specific market in China.

Published in Poultry Science

ISSN: 0032-5791 (Print); 1525-3171 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Agriculture: Animal culture
Website: https://www.journals.elsevier.com/poultry-science

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