Nature Communications (Jul 2022)
Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice
- Aki Takahashi,
- Romain Durand-de Cuttoli,
- Meghan E. Flanigan,
- Emi Hasegawa,
- Tomomi Tsunematsu,
- Hossein Aleyasin,
- Yoan Cherasse,
- Ken Miya,
- Takuya Okada,
- Kazuko Keino-Masu,
- Koshiro Mitsui,
- Long Li,
- Vishwendra Patel,
- Robert D. Blitzer,
- Michael Lazarus,
- Kenji F. Tanaka,
- Akihiro Yamanaka,
- Takeshi Sakurai,
- Sonoko Ogawa,
- Scott J. Russo
Affiliations
- Aki Takahashi
- Laboratory of Behavioral Neurobiology, Faculty of Human Sciences, University of Tsukuba
- Romain Durand-de Cuttoli
- Nash Family Department of Neuroscience and Brain & Body Research Center, Icahn School of Medicine at Mount Sinai
- Meghan E. Flanigan
- Nash Family Department of Neuroscience and Brain & Body Research Center, Icahn School of Medicine at Mount Sinai
- Emi Hasegawa
- Department of Molecular Behavioral Physiology, Faculty of Medicine, University of Tsukuba
- Tomomi Tsunematsu
- Super-network Brain Physiology, Graduate School of Life Sciences, Tohoku University
- Hossein Aleyasin
- Nash Family Department of Neuroscience and Brain & Body Research Center, Icahn School of Medicine at Mount Sinai
- Yoan Cherasse
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Ken Miya
- Department of Molecular Neurobiology, Faculty of Medicine, University of Tsukuba
- Takuya Okada
- Department of Molecular Neurobiology, Faculty of Medicine, University of Tsukuba
- Kazuko Keino-Masu
- Department of Molecular Neurobiology, Faculty of Medicine, University of Tsukuba
- Koshiro Mitsui
- Laboratory of Behavioral Neurobiology, Faculty of Human Sciences, University of Tsukuba
- Long Li
- Nash Family Department of Neuroscience and Brain & Body Research Center, Icahn School of Medicine at Mount Sinai
- Vishwendra Patel
- Department of Pharmacological Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Robert D. Blitzer
- Department of Pharmacological Sciences and Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Michael Lazarus
- International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
- Kenji F. Tanaka
- Department of Neuropsychiatry, Keio University School of Medicine
- Akihiro Yamanaka
- Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University
- Takeshi Sakurai
- Department of Molecular Behavioral Physiology, Faculty of Medicine, University of Tsukuba
- Sonoko Ogawa
- Laboratory of Behavioral Neuroendocrinology, Faculty of Human Sciences, University of Tsukuba
- Scott J. Russo
- Nash Family Department of Neuroscience and Brain & Body Research Center, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-022-31728-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
The dorsal raphe nucleus (DRN) is known to modulate aggressive behaviour in rodents. Here the authors show that glutamatergic projections from the lateral habenula to DRN modulate aggression between male mice.
