mSphere (Jun 2021)
Temporal Dynamics and Evolution of SARS-CoV-2 Demonstrate the Necessity of Ongoing Viral Genome Sequencing in Ontario, Canada
- Calvin P. Sjaarda,
- Jennifer L. Guthrie,
- Samira Mubareka,
- Jared T. Simpson,
- Bettina Hamelin,
- Henry Wong,
- Leanne Mortimer,
- Robert Slinger,
- Andrew G. McArthur,
- Marc Desjardins,
- Allison McGeer,
- Tony Mazzulli,
- Katya Douchant,
- Danielle Brabant-Kirwan,
- Ramzi Fattouh,
- Aaron Campigotto,
- Samir N. Patel,
- Nahuel Fittipaldi,
- Robert I. Colautti,
- Prameet M. Sheth
Affiliations
- Calvin P. Sjaarda
- ORCiD
- Department of Psychiatry, Queen’s University, Kingston, Ontario, Canada
- Jennifer L. Guthrie
- Public Health Ontario, Toronto, Ontario, Canada
- Samira Mubareka
- Sunnybrook Health Science Centre, Division of Infectious Diseases, Toronto, Ontario, Canada
- Jared T. Simpson
- Ontario Institute for Cancer Research, Toronto, Ontario, Canada
- Bettina Hamelin
- Ontario Genomics Institute, Toronto, Ontario, Canada
- Henry Wong
- Division of Microbiology, Kingston Health Sciences Centre, Kingston, Ontario, Canada
- Leanne Mortimer
- Division of Microbiology, Eastern Ontario Regional Laboratories, Ottawa, Ontario, Canada
- Robert Slinger
- Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada
- Andrew G. McArthur
- ORCiD
- Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
- Marc Desjardins
- Division of Microbiology, Eastern Ontario Regional Laboratories, Ottawa, Ontario, Canada
- Allison McGeer
- Department of Microbiology, Mount Sinai Hospital, University Health Network, Toronto, Ontario, Canada
- Tony Mazzulli
- Public Health Ontario, Toronto, Ontario, Canada
- Katya Douchant
- Department of Biomedical & Molecular Sciences, Queen’s University, Kingston, Ontario, Canada
- Danielle Brabant-Kirwan
- Division of Microbiology, Health Sciences North, Sudbury, Ontario, Canada
- Ramzi Fattouh
- St. Michael’s Unity Health, Toronto, Ontario, Canada
- Aaron Campigotto
- Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
- Samir N. Patel
- Public Health Ontario, Toronto, Ontario, Canada
- Nahuel Fittipaldi
- Public Health Ontario, Toronto, Ontario, Canada
- Robert I. Colautti
- Biology Department, Queen’s University, Kingston, Ontario, Canada
- Prameet M. Sheth
- Division of Microbiology, Kingston Health Sciences Centre, Kingston, Ontario, Canada
- DOI
- https://doi.org/10.1128/mSphere.00011-21
- Journal volume & issue
-
Vol. 6,
no. 3
Abstract
Genome-wide variation in SARS-CoV-2 reveals evolution and transmission dynamics which are critical considerations for disease control and prevention decisions. Here, we review estimates of the genome-wide viral mutation rates, summarize current COVID-19 case load in the province of Ontario, Canada (5 January 2021), and analyze published SARS-CoV-2 genomes from Ontario (collected prior to 24 November 2020) to test for more infectious genetic variants or lineages.
