Hypertension in Pregnancy (Apr 2019)

External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort

  • Marije Lamain-de Ruiter,
  • Anneke Kwee,
  • Christiana A. Naaktgeboren,
  • Rebecca D. Louhanepessy,
  • Inge De Groot,
  • Inge M. Evers,
  • Floris Groenendaal,
  • Yolanda R. Hering,
  • Anjoke J. M. Huisjes,
  • Cornel Kirpestein,
  • Wilma M. Monincx,
  • Peter C. J. I. Schielen,
  • Annewil Van ’T Zelfde,
  • Charlotte M. Van Oirschot,
  • Simone A. Vankan-Buitelaar,
  • Mariska A. A. W. Vonk,
  • Therese A. Wiegers,
  • Joost J. Zwart,
  • Karel G. M. Moons,
  • Arie Franx,
  • Maria P. H. Koster

DOI
https://doi.org/10.1080/10641955.2019.1584210
Journal volume & issue
Vol. 38, no. 2
pp. 78 – 88

Abstract

Read online

Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Methods: Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. Results: 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Conclusion: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.

Keywords