Decoding Cold Therapy Mechanisms of Enhanced Bone Repair through Sensory Receptors and Molecular Pathways

Abstract

Applying cold to a bone injury can aid healing, though its mechanisms are complex. This study investigates how cold therapy impacts bone repair to optimize healing. Cold was applied to a rodent bone model, with the physiological responses analyzed. Vasoconstriction was mediated by an increase in the transient receptor protein channels (TRPs), transient receptor potential ankyrin 1 (TRPA1; p = 0.012), and transient receptor potential melastatin 8 (TRPM8; p p p p = 0.039) and RNA-binding motif protein 3 (RBM3; p p = 0.021) and 10 (two-fold, p p = 0.019), indicating the presence of mature osteoblasts capable of mineralization. These findings highlight cold therapy’s multifaceted effects on bone repair, offering insights for therapeutic strategies.

Keywords

• cold
• bone healing
• tissue engineering
• hypoxia
• vasculature
• osteogenesis